Zheng Na, Yao Feihua, Liang Xuefeng, Liu Quan, Xu Weifeng, Liang Yan, Liu Xiaobo, Li Jun, Yang Ruiyun
a State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources , College of Chemistry and Pharmaceutical Sciences, Guangxi Normal University , Guilin , P.R. China.
Nat Prod Res. 2018 Apr;32(7):755-760. doi: 10.1080/14786419.2017.1311892. Epub 2017 Apr 7.
A new phthalide derivative, xylarphthalide A (1), along with two known compounds (-)-5-carboxylmellein (2) and (-)-5-methylmellein (3), were isolated from the endophytic fungus Xylaria sp. GDG-102 cultured from the Chinese medicinal plant Sophora tonkinensis. Their structures were identified by MS and NMR experiments, and the absolute configuration of 1 was further confirmed by single-crystal X-ray diffraction analysis. Compound 1-3 showed antibacterial activities against Bacillus megaterium, Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Shigella dysenteriae with MIC values of 12.5-25 μg/mL.
从中国药用植物越南槐中培养的内生真菌炭角菌属Xylaria sp. GDG-102中分离出一种新的苯酞衍生物木犀苯酞A（1），以及两种已知化合物（-）-5-羧基水犀草素（2）和（-）-5-甲基水犀草素（3）。通过质谱和核磁共振实验确定了它们的结构，并通过单晶X射线衍射分析进一步确证了1的绝对构型。化合物1-3对巨大芽孢杆菌、枯草芽孢杆菌、金黄色葡萄球菌、大肠杆菌和痢疾志贺氏菌具有抗菌活性，最低抑菌浓度值为12.5-25μg/mL。
