China Pharmaceutical Culture Collection, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
Immunology Division, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
J Antibiot (Tokyo). 2023 Oct;76(10):613-617. doi: 10.1038/s41429-023-00640-z. Epub 2023 Jul 4.
There are six new phthalide derivatives Verbalide A ~ F (1-6) together with another known derivative (7) isolated from the endophytic fungus Preussia sp. CPCC 400972. Their structures were established by comprehensive spectroscopic analyses, including NMR and HRESIMS. In addition, compounds 1-7 exhibited excellent inhibitory effect against influenza A virus.
从内生真菌 Preussia sp. CPCC 400972 中分离得到了 6 种新的苯酞衍生物 Verbalide A~F（1-6）和另一种已知衍生物（7）。通过包括 NMR 和 HRESIMS 在内的综合光谱分析确定了它们的结构。此外，化合物 1-7 对甲型流感病毒表现出优异的抑制作用。
