Department of Toxicology, School of Public Health, Anhui Medical University, China; Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes, China.
Department of Toxicology, School of Public Health, Anhui Medical University, China.
Ecotoxicol Environ Saf. 2022 Mar 15;233:113313. doi: 10.1016/j.ecoenv.2022.113313. Epub 2022 Feb 16.
A few studies have reported phthalate exposure as a risk factor for depressive symptoms, but the results have been inconsistent. Whether chronic inflammation mediates the relationship between phthalates (PAEs) and depressive symptoms remains unclear. In this study, we establish mediating models of inflammatory factors and explore the mediating role of chronic inflammation in the association between PAEs exposure and depressive symptoms.
The sample included 989 participants from the Study on Health and Environment of the Elderly in Lu'an City, Anhui Province. Geriatric depression scale (GDS-30) was used to screen depressive symptoms of the elderly. The levels of seven kinds of PAEs in urine samples and four inflammatory factors in serum of the elderly were measured. To establish the mediating effect of inflammatory factors to explore the potential effect of PAEs exposure on the increased odds of depressive symptoms.
Adjusted for multiple variables, the highest tertiles of Mono (2-ethylhexyl) phthalate (MEHP) (95%CI = 1.051-2.112), Mono benzyl phthalate (MBzP) (95%CI = 1.016-2.082) and Mono butyl phthalate (MBP) (95%CI = 1.102-2.262) were positively correlated with depressive symptoms. The mediating effect of IL-6 and generalized inflammation factor between MEHP exposure and depressive symptoms were 15.96% (95%CI=0.0288-0.1971) and 14.25% (95%CI = 0.0167-0.1899).
High levels of MEHP, MBzP and MBP increased the odds of depressive symptoms in the elderly, and chronic inflammation had a partial mediating effect on the increased odds of depressive symptoms due to MEHP exposure.
一些研究报告称邻苯二甲酸酯（PAEs）暴露是抑郁症状的一个危险因素，但结果并不一致。PAEs 暴露与抑郁症状之间的关系是否与慢性炎症有关尚不清楚。在本研究中，我们建立了炎症因子的中介模型，探讨了慢性炎症在 PAEs 暴露与抑郁症状之间关联中的中介作用。
该样本包括来自安徽省六安市老年人健康与环境研究的 989 名参与者。采用老年抑郁量表（GDS-30）筛查老年人的抑郁症状。测量老年人尿液中 7 种 PAEs 水平和血清中 4 种炎症因子水平。建立炎症因子的中介效应模型，以探讨 PAEs 暴露对抑郁症状发生率增加的潜在影响。
调整多个变量后，最高 tertiles 的邻苯二甲酸单（2-乙基己基）酯（MEHP）（95%CI=1.051-2.112）、邻苯二甲酸单苄基酯（MBzP）（95%CI=1.016-2.082）和邻苯二甲酸单丁基酯（MBP）（95%CI=1.102-2.262）与抑郁症状呈正相关。MEHP 暴露与抑郁症状之间的 IL-6 和全身炎症因子的中介效应分别为 15.96%（95%CI=0.0288-0.1971）和 14.25%（95%CI=0.0167-0.1899）。
高水平的 MEHP、MBzP 和 MBP 增加了老年人抑郁症状的发生率，慢性炎症对 MEHP 暴露导致的抑郁症状发生率增加具有部分中介作用。
