Translational Medicine Research Center, Zhujiang Hospital, Southern Medical University/The Second School of Clinical Medicine, Southern Medical University, Guangzhou, 510515, Guangdong, China.
Cancer Research Institute, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China.
J Nanobiotechnology. 2022 Feb 19;20(1):87. doi: 10.1186/s12951-022-01292-1.
UV exposure continues to induce many health issues, though commercial sunscreens are available. Novel UV filters with high safety and efficacy are urgently needed. Metal-organic frameworks (MOFs) could be a suitable platform for UV filter development, due to their tunable optical, electrical, and photoelectric properties by precise controlled synthesis.
Herein, four zinc-based MOFs with various bandgap energies were chose to investigate their optical behaviors and evaluate their possibility as sunscreens. Zeolitic imidazolate framework-8 (ZIF-8) was found to possess the highest and widest UV reflectance, thereby protecting against sunburn and DNA damage on mouse skin and even achieving a comparable or higher anti-UV efficacy relative to the commercially available UV filters, TiO or ZnO, on pig skin, a model that correlates well with human skin. Also, ZIF-8 exerted appealing characteristics for topical skin use with low radical production, low skin penetration, low toxicity, high transparency, and high stability.
These results confirmed ZIF-8 could potentially be a safe and effective sunscreen surrogate for human, and MOFs could be a novel source to develop more effective and safe UV filters.
尽管市售防晒霜可用，但紫外线暴露仍会引发诸多健康问题。因此，急需具有高安全性和功效的新型紫外线滤光剂。由于金属-有机骨架（MOFs）可以通过精确控制合成来调节其光学、电学和光电性能，因此它们可能是开发紫外线滤光剂的合适平台。
本文选择了四种具有不同能带隙能量的锌基 MOFs 来研究它们的光学行为，并评估它们作为防晒霜的可能性。沸石咪唑酯骨架-8（ZIF-8）被发现具有最高和最宽的紫外线反射率，从而能够防止晒伤和 DNA 损伤，在小鼠皮肤甚至在猪皮上，与人体皮肤相关性良好的模型中，其具有与市售紫外线滤光剂 TiO 或 ZnO 相当或更高的抗紫外线功效。此外，ZIF-8 具有低自由基生成、低皮肤穿透性、低毒性、高透明度和高稳定性等特点，非常适合局部皮肤使用。
这些结果证实 ZIF-8 可能是一种安全有效的人体防晒霜替代品，MOFs 可能是开发更有效和安全的紫外线滤光剂的新来源。
