Jones A S, Lancer J M, Shone G, Stevens J C
Acta Otolaryngol. 1986 Mar-Apr;101(3-4):328-30. doi: 10.3109/00016488609132846.
The effect of lignocaine on nasal sensation of airflow and nasal resistance was assessed in twenty-five subjects. A randomised crossover trial was conducted with lignocaine as the active drug and saline as the placebo. Both substances were delivered to the nasal mucosa as a nasal spray. Lignocaine caused a sensation of increased nasal patency in twenty-two of the twenty-five subjects studied. Saline had no such effect. The difference between this subjective effect of the two substances was highly significant (p less than 0.001). Neither spray had any significant effect on nasal resistance to airflow assessed objectively by rhinomanometry.
在25名受试者中评估了利多卡因对鼻气流感觉和鼻阻力的影响。以利多卡因为活性药物，生理盐水为安慰剂进行了一项随机交叉试验。两种物质均作为鼻喷雾剂输送至鼻黏膜。在25名受试对象中，有22名使用利多卡因后感觉鼻腔通畅度增加。生理盐水则无此效果。这两种物质的这种主观效应之间的差异非常显著（p小于0.001）。两种喷雾剂对通过鼻阻力计客观评估的鼻气流阻力均无显著影响。
