Balint G A, Náfrádi J, Varró V
Agents Actions. 1986 Mar;17(5-6):495-7. doi: 10.1007/BF01965520.
It seems that the gastric antral mucosa either in normal, physiological circumstances, or in IND or STR induced gastric ulcer models, contains significantly more endogenous PG-I2 than that of gastric fundic mucosa, while the duodenal mucosa contains significantly lower endogenous PG-I2-level compared to the gastric antral or fundic level. Either in gastric or in duodenal ulceration the endogenous PG-I2 level basically decreased proportionally to the degree of ulceration - therefore it is tempting to speculate that the endogenous PG-I2 is most probably one of the natural protective substances in the gastrointestinal mucosa.
在正常生理情况下，以及在吲哚美辛（IND）或应激（STR）诱导的胃溃疡模型中，胃窦黏膜所含的内源性前列环素（PG-I2）似乎明显多于胃底黏膜，而十二指肠黏膜的内源性PG-I2水平明显低于胃窦或胃底黏膜。无论是胃溃疡还是十二指肠溃疡，内源性PG-I2水平基本都与溃疡程度成比例下降——因此，很容易推测内源性PG-I2很可能是胃肠道黏膜中的天然保护物质之一。
