Balint G A, Varró V
Agents Actions. 1986 Nov;19(3-4):224-7. doi: 10.1007/BF01966210.
In our opinion the endogenous prostacyclin (PGI2) is one of the most important natural protective substances in the gastric mucosa. We have, therefore checked in experimental circumstances in rats, as well as in clinical observations in humans, the possible effect of smoking on endogenous gastroduodenal mucosal PGI2 level. The animal experiments seem to verify that cigarette smoke really has an unwanted effect on the gastric mucosa. The target of this action is the endogenous PGI2 content of the mucosa. According to our observations in humans there is a definite tendency toward decreased endogenous PGI2 production in the gastroduodenal mucosa of smokers too.
我们认为内源性前列环素（PGI2）是胃黏膜中最重要的天然保护物质之一。因此，我们在大鼠的实验环境以及人类的临床观察中，研究了吸烟对胃十二指肠黏膜内源性PGI2水平的可能影响。动物实验似乎证实香烟烟雾确实对胃黏膜有不良影响。这种作用的靶点是黏膜的内源性PGI2含量。根据我们对人类的观察，吸烟者胃十二指肠黏膜内源性PGI2的产生也有明显下降的趋势。
