Department of Chemical Engineering, Rochester Institute of Technology, Rochester, NY, 14623, United States.
Anal Chim Acta. 2022 May 8;1206:339226. doi: 10.1016/j.aca.2021.339226. Epub 2021 Oct 30.
Glucose detection is of vital importance to diabetes diagnosis and treatment. Optical approaches in glucose sensing have received much attention in recent years due to the relatively low cost, portable, and mini-invasive or non-invasive potentials. Surface enhanced Raman spectroscopy (SERS) endows the benefits of extremely high sensitivity because of enhanced signals and specificity due to the fingerprint of molecules of interest. However, the direct detection of glucose through SERS was challenging because of poor adsorption of glucose on bare metals and low cross section of glucose. In order to address these challenges, several approaches were proposed and utilized for glucose detection through SERS. This review article mainly focuses on the development of surface enhanced Raman scattering based glucose sensors in recent 10 years. The sensing mechanisms, rational design and sensing properties to glucose are reviewed. Two strategies are summarized as intrinsic sensing and extrinsic sensing. Four general categories for glucose sensing through SERS are discussed including SERS active platform, partition layer functionalized surface, boronic acid based sensors, and enzymatic reaction based biosensors. Finally, the challenges and outlook for SERS based glucose sensors are also presented.
葡萄糖检测对糖尿病的诊断和治疗至关重要。近年来，由于光学方法在葡萄糖传感方面具有成本相对较低、便携、微创或非侵入性等潜在优势，因此受到了广泛关注。表面增强拉曼光谱（SERS）由于增强的信号和由于感兴趣分子的指纹而具有的特异性，赋予了极高灵敏度的优点。然而，由于葡萄糖在裸金属上的吸附不良和葡萄糖的低横截面积，通过 SERS 直接检测葡萄糖具有挑战性。为了解决这些挑战，提出并利用了几种方法通过 SERS 进行葡萄糖检测。本文主要综述了近 10 年来基于表面增强拉曼散射的葡萄糖传感器的发展。综述了传感机制、合理设计和对葡萄糖的传感特性。总结了两种策略，即本征传感和外传感。讨论了通过 SERS 进行葡萄糖传感的四个一般类别，包括 SERS 活性平台、分区层功能化表面、硼酸基传感器和基于酶反应的生物传感器。最后，还提出了基于 SERS 的葡萄糖传感器面临的挑战和展望。
