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前凸型多孔椎间融合器引起的相邻节段生物力学变化。

Biomechanical changes at the adjacent segments induced by a lordotic porous interbody fusion cage.

作者信息

Zhang Ning-Ze, Xiong Qi-Sheng, Yao Jie, Liu Bo-Lun, Zhang Min, Cheng Cheng-Kung

机构信息

Key Laboratory of Biomechanics and Mechanobiology, Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, 100083, China.

Key Laboratory of Biomechanics and Mechanobiology, Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, 100083, China.

出版信息

Comput Biol Med. 2022 Apr;143:105320. doi: 10.1016/j.compbiomed.2022.105320. Epub 2022 Feb 14.

Abstract

Biomechanical changes at the adjacent segments after interbody fusion are common instigators of adjacent segment degeneration (ASD). This study aims to investigate how the presence of a lordotic porous cage affects the biomechanical performance of the adjacent segments. A finite element model (FEM) of a lumbar spine implanted with a lordotic cage at L3-L4 was validated by in-vitro testing. The stress distribution on the cage and range of motion (ROM) of L3-L4 were used to assess the stability of the implant. Three angles of cage (0° = non-restoration, 7° = normal restoration and 11° = over-restoration) were modelled with different porosities (0%, 30% and 60%) and evaluated in the motions of flexion, extension, lateral bending and rotation. The ROM, intervertebral disc pressure (IDP) and facet joint force (FJF) were used to evaluate biomechanical changes at the adjacent segments in each model. The results indicated that porous cages produced more uniform stress distribution, but cage porosity did not influence the ROM, IDP and FJF at L2-L3 and L4-L5. Increasing the cage lordotic angle acted to decrease the ROM and IDP, and increase the FJF of L4-L5, but did not alter the ROM of L2-L3. In conclusion, changes in ROM, IDP and FJF at the adjacent segments were mainly influenced by the lordotic angle of the cage and not by the porosity. A larger angle of lordotic cage was shown to reduce the ROM and IDP, and increase the FJF of the lower segment (L4-L5), but had little effect on the ROM of the upper segment (L2-L3).

摘要

椎间融合术后相邻节段的生物力学变化是相邻节段退变(ASD)的常见诱因。本研究旨在探讨前凸多孔椎间融合器的存在如何影响相邻节段的生物力学性能。通过体外测试验证了在L3-L4植入前凸椎间融合器的腰椎有限元模型(FEM)。使用椎间融合器上的应力分布和L3-L4的活动度(ROM)来评估植入物的稳定性。模拟了三种角度的椎间融合器(0°=无恢复,7°=正常恢复,11°=过度恢复),其具有不同的孔隙率(0%、30%和60%),并在屈伸、侧屈和旋转运动中进行评估。使用ROM、椎间盘压力(IDP)和小关节力(FJF)来评估每个模型中相邻节段的生物力学变化。结果表明,多孔椎间融合器产生更均匀的应力分布,但椎间融合器的孔隙率不影响L2-L3和L4-L5的ROM、IDP和FJF。增加椎间融合器的前凸角度会降低L4-L5的ROM和IDP,并增加FJF,但不会改变L2-L3的ROM。总之,相邻节段ROM、IDP和FJF的变化主要受椎间融合器前凸角度的影响,而非孔隙率。结果显示,更大角度的前凸椎间融合器可降低ROM和IDP,并增加下节段(L4-L5)的FJF,但对上节段(L2-L3)的ROM影响不大。

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