Drost Jennifer M, Cook Curtiss B, Spangehl Mark J, Probst Nicholas E, Mi Lanyu, Trentman Terrence L
Departments of Anesthesiology (JMD, TLT), Mayo Clinic Arizona, Phoenix, Arizona.
Endocrinology (CBC), Mayo Clinic Arizona, Phoenix, Arizona.
Am J Lifestyle Med. 2019 Oct 22;16(1):150-154. doi: 10.1177/1559827619879073. eCollection 2022 Jan-Feb.
The purpose of this study was to assess the feasibility and effectiveness of a whole food plant-based diet (WFPBD) to improve day of surgery fasting blood glucose (FBG) among patients with type 2 diabetes (T2D). Ten patients with T2D scheduled for a total hip or total knee replacement were recruited. For 3 weeks preceding their surgeries, subjects were asked to consume an entirely WFPBD. Frozen WFPBD meals were professionally prepared and delivered to each participant for the 3 weeks prior to surgery. FBG was reassessed on the morning of surgery and compared with preintervention values. Compliance with the diet was assessed. Mean age of subjects and reported duration of diabetes was 65 and 8 years, respectively, average hemoglobin A1c (HbA1c) was 6.6%, and 6 were women. Mean FBG decreased from 127 to 116 mg/dL ( = .2). Five of the subjects experienced improvement in glycemic control, with an average decline of 11 mg/dL. A WFPBD is a potentially effective intervention to improve glycemic control among patients with T2D during the period leading up to surgery. Future controlled trials on a larger sample of patients to assess the impact of a WFPBD on glycemic control and surgical outcomes are warranted.
本研究的目的是评估全植物性食物饮食(WFPBD)改善2型糖尿病(T2D)患者手术日空腹血糖(FBG)的可行性和有效性。招募了10名计划进行全髋关节或全膝关节置换术的T2D患者。在手术前3周,要求受试者食用完全的WFPBD。在手术前3周,为每位参与者专业准备并提供冷冻的WFPBD餐食。在手术当天早晨重新评估FBG,并与干预前的值进行比较。评估饮食依从性。受试者的平均年龄和报告的糖尿病病程分别为65岁和8年,平均糖化血红蛋白(HbA1c)为6.6%,6名是女性。平均FBG从127降至116mg/dL(P = 0.2)。5名受试者的血糖控制得到改善,平均下降11mg/dL。WFPBD是一种在手术前期间改善T2D患者血糖控制的潜在有效干预措施。未来有必要对更大样本的患者进行对照试验,以评估WFPBD对血糖控制和手术结果的影响。