一种由全血细胞计数组成的风险模型，可预测儿童朗格汉斯细胞组织细胞增多症的不良预后。
A Risk Model Composed of Complete Blood Count, and Predicts Inferior Prognosis of Langerhans Cell Histiocytosis in Children.
作者信息
Wang Leyuan, Yuan Lin, Du Xizi, Zhou Kai, Yang Yu, Qin Qingwu, Yang Liangchun, Xiang Yang, Qu Xiangping, Liu Huijun, Qin Xiaoqun, Liu Chi
机构信息
Department of Physiology, School of Basic Medicine Science, Central South University, Changsha, China.
Department of Respiratory and Critical Care Medicine, The Second Xiangya Hospital, Central South University, Changsha, China.
出版信息
Front Oncol. 2022 Feb 4;12:800786. doi: 10.3389/fonc.2022.800786. eCollection 2022.
BACKGROUND
In children, Langerhans cell histiocytosis (LCH), which is the most prevalent histiocytic disorder, exhibits a wide variety of manifestations and outcomes. There is no standard prognosis evaluation system for LCH. We investigated the combined predictive significance of complete blood counts (CBCs), and in childhood LCH.
METHODS
A cohort of 71 childhood LCH patients was retrospectively studied. The prognosis predictive significance of platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), systemic inflammation response index (SIRI), systemic immune inflammation index (SII), , and were analyzed.
RESULTS
Histiocyte Society (HS) classification of LCH patients was correlated with NLR, SIRI, and progression free survival (PFS), bone involvement was correlated with SIRI, liver involvement was correlated with NLR, SII, SIRI, and PFS, spleen involvement was correlated with SIRI, lung involvement was correlated with NLR and PFS, CNS involvement was correlated with PFS, while was correlated with PLR, NLR, SIRI, SII, PFS, and OS ( <0.05). was correlated with NLR, SIRI, PFS, and OS ( <0.05). Elevated NLR, PLR SIRI, and SII predicted inferior PFS and OS (0.05). PLR, NLE, SIRI, SII, , and were used to establish a risk model for stratifying the LCH patients into 3 different risk groups. Respective median PFS for low-, mediate-, and high-risk groups were not reached, 26, and 14 months ( <0.001), and all median OS were not reached ( <0.001).
CONCLUSION
The risk model combined with CBCs, , and might be a promising prognostic system for LCH in children.
背景
在儿童中，朗格汉斯细胞组织细胞增多症（LCH）是最常见的组织细胞疾病，表现形式和预后多种多样。目前尚无LCH的标准预后评估系统。我们研究了全血细胞计数（CBC）以及[此处原文缺失部分内容]在儿童LCH中的联合预测意义。
方法
对71例儿童LCH患者进行回顾性研究。分析血小板与淋巴细胞比值（PLR）、中性粒细胞与淋巴细胞比值（NLR）、全身炎症反应指数（SIRI）、全身免疫炎症指数（SII）以及[此处原文缺失部分内容]的预后预测意义。
结果
LCH患者的组织细胞协会（HS）分类与NLR、SIRI和无进展生存期（PFS）相关，骨受累与SIRI相关，肝受累与NLR、SII、SIRI和PFS相关，脾受累与SIRI相关，肺受累与NLR和PFS相关，中枢神经系统受累与PFS相关，而[此处原文缺失部分内容]与PLR、NLR、SIRI、SII、PFS和总生存期（OS）相关（P<0.05）。[此处原文缺失部分内容]与NLR、SIRI、PFS和OS相关（P<0.05）。NLR、PLR、SIRI和SII升高预示着较差的PFS和OS（P<0.05）。使用PLR、NLE、SIRI、SII以及[此处原文缺失部分内容]建立了一个风险模型，将LCH患者分为3个不同风险组。低、中、高风险组的各自中位PFS分别为未达到中位数、26个月和14个月（P<0.001），所有中位OS均未达到中位数（P<0.001）。
结论
结合CBC以及[此处原文缺失部分内容]的风险模型可能是一种有前景的儿童LCH预后评估系统。
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