铜介导的3-吲哚乙酸与吡唑啉酮的脱羧偶联反应
Copper-Mediated Decarboxylative Coupling of 3-Indoleacetic Acids with Pyrazolones.
作者信息
Wen Kangmei, Wu Yinrong, Chen Jiewen, Shi Jie, Zheng Mulin, Yao Xingang, Tang Xiaodong
机构信息
Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, 1023 South Shatai Road, Baiyun District, Guangzhou 510515, People's Republic of China.
出版信息
ACS Omega. 2022 Feb 2;7(6):5274-5282. doi: 10.1021/acsomega.1c06443. eCollection 2022 Feb 15.
A copper-mediated decarboxylative coupling reaction of 3-indoleacetic acids with pyrazolones was described. This protocol realized new functionalization of pyrazolones under simple reaction conditions and exhibited high functional group compatibility and broad substrate scope. Notably, the products displayed antiproliferative activity against cancer cells.
描述了一种铜介导的3-吲哚乙酸与吡唑啉酮的脱羧偶联反应。该方法在简单的反应条件下实现了吡唑啉酮的新功能化，具有高官能团兼容性和广泛的底物范围。值得注意的是，产物对癌细胞显示出抗增殖活性。
Zotero 插件