Zarlengo K M, Battaglia F C, Fennessey P, Hay W W
Biol Neonate. 1986;49(4):181-9. doi: 10.1159/000242529.
Within the neonatal euglycemic range, we studied the relationships among total glucose entry, intravenous glucose infusion, endogenous glucose production, glucose disposal rate and blood glucose concentration in infants less than or equal to 32 weeks gestation. [U-13C]-glucose was used as a tracer of glucose metabolism, administered as a primed constant infusion. Using a glucose clamp technique, at least one steady-state period of blood glucose concentration in 10 infants and two steady-state periods of blood glucose concentration in 6 infants were achieved. In the 6 infants studied at 2 glucose concentrations, glucose disposal rate increased with blood glucose concentration, r = 0.95, p less than 0.01, slope = 0.091 +/- 0.058 (SD) mg X min-1 X kg-1 per mg X dl-1 of glucose concentration increase. In all infants studied, intravenous glucose infusion rate was not different from glucose disposal rate, suggesting the absence of endogenous glucose production.
在新生儿血糖正常范围内，我们研究了胎龄小于或等于32周的婴儿的总葡萄糖摄入量、静脉葡萄糖输注量、内源性葡萄糖生成量、葡萄糖处置率和血糖浓度之间的关系。[U-13C] -葡萄糖用作葡萄糖代谢的示踪剂，通过首剂恒速输注给药。采用葡萄糖钳夹技术，10名婴儿至少达到了一个血糖浓度稳态期，6名婴儿达到了两个血糖浓度稳态期。在6名接受两种葡萄糖浓度研究的婴儿中，葡萄糖处置率随血糖浓度升高而增加，r = 0.95，p < 0.01，斜率为每增加1mg/dl葡萄糖浓度0.091±0.058（标准差）mg·min-1·kg-1。在所有研究的婴儿中，静脉葡萄糖输注率与葡萄糖处置率无差异，提示无内源性葡萄糖生成。
