Zhang Meng, Jin Chen, Kong Xiangbin, Meng Jialin, Fan Song, Ding Yang, Fang Qiaozhou, Dong Ting, Zhang Houliang, Ni Jinliang, Liu Yi, Wang Hua, Chen Xianguo, Hao Zongyao, Peng Bo, Zhang Li, Wang Zhiping, Liang Chaozhao
Department of Urology, The First Affiliated Hospital of Anhui Medical University, Institute of Urology & Anhui Province Key Laboratory of Genitourinary Diseases, Anhui Medical University, Hefei, Anhui, PR China.
Shenzhen Luohu Hospital Group, Institute of Urology of Shenzhen University, The Third Affiliated Hospital of Shenzhen University, Shenzhen, PR China.
Prostate. 2022 May;82(7):772-782. doi: 10.1002/pros.24319. Epub 2022 Feb 21.
We aimed to systematically identify novel susceptible factors related to the occurrence and development of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS)-like symptoms that were not limited to lifestyles or dietary habits in Chinese population.
We recruited participants from three centers (Shanghai [northeast], Hefei [east], and Lanzhou [northwest]) from August 2020 to June 2021. Demographics, lifestyles, dietary habits, past medical history, and national institutes of health-chronic prostatitis symptom index (NIH-CPSI) were collected from the individuals via optimized questionnaires. Logistic regression analysis and multivariate adjustment models were used to calculate the odds ratio (OR) and 95% confidence interval (95% CI) to assess the association between these variables and CP/CPPS-like symptoms.
A total of 1851 participants were enrolled in this study (764 cases and 1087 controls). Age distributions differed between groups (median, range: 32, 18-74 vs. 29, 18-70, p < 0.001). After adjustment, physicochemical occupational hazards were identified significantly related to CP/CPPS-like symptom occurrence and development (OR : 1.389, 95% CI: 1.031-1.870, p < 0.001; OR : 2.222, 95% CI: 1.464-3.372, p < 0.001); besides, greater than or equal to four ejaculations per week significantly increased the likelihood of CP/CPPS-like symptoms compared with one ejaculation per week (OR : 3.051, 95% CI: 1.598-5.827, p = 0.001). For these patients, who were easily felt gastrointestinal discomfort caused by spicy food intake, they had a higher incidence to affect with CP/CPPS-like symptoms (OR : 2.258, 95% CI: 1.858-2.745, p < 0.001). In addition, history of drug allergy and genitourinary infections were identified as independent susceptible factors for the occurrence of CP/CPPS-like symptoms (OR : 1.689, 95% CI: 1.007-2.834, p = 0.047; OR : 3.442, 95% CI: 2.202-5.382, p < 0.001, respectively), while the history of rheumatic immune diseases was found tightly associated with the development of CP/CPPS-like symptoms (OR : 2.002, 95% CI: 1.008-4.058, p = 0.048).
Infection/inflammatory/immune-related disorders, novel dietary habits, and lifestyles associated with the susceptibility of CP/CPPS-like symptoms' occurrence and development are identified. Altering these irregular conditions serves as potential strategies for the treatment of patients with CP/CPPS-like symptoms.
我们旨在系统地识别与中国人群慢性前列腺炎/慢性盆腔疼痛综合征（CP/CPPS）样症状发生和发展相关的新的易感因素，这些因素不限于生活方式或饮食习惯。
2020年8月至2021年6月，我们从三个中心（上海[东北部]、合肥[东部]和兰州[西北部]）招募参与者。通过优化问卷收集个体的人口统计学、生活方式、饮食习惯、既往病史和美国国立卫生研究院慢性前列腺炎症状指数（NIH-CPSI）。采用逻辑回归分析和多变量调整模型计算比值比（OR）和95%置信区间（95%CI），以评估这些变量与CP/CPPS样症状之间的关联。
本研究共纳入1851名参与者（764例病例和1087例对照）。两组年龄分布不同（中位数，范围：32岁，18 - 74岁 vs. 29岁，18 - 70岁，p < 0.001）。调整后，确定物理化学职业危害与CP/CPPS样症状的发生和发展显著相关（OR : 1.389，95%CI: 1.031 - 1.870，p < 0.001；OR : 2.222，95%CI: 1.464 - 3.372，p < 0.001）；此外，每周射精≥4次与每周射精1次相比，显著增加了CP/CPPS样症状的发生可能性（OR : 3.051，95%CI: 1.598 - 5.827，p = 0.001）。对于这些容易因摄入辛辣食物而感到胃肠道不适的患者，他们患CP/CPPS样症状的发生率更高（OR : 2.258，95%CI: 1.858 - 2.745，p < 0.001）。此外，药物过敏史和泌尿生殖系统感染被确定为CP/CPPS样症状发生的独立易感因素（OR分别为1.689，95%CI: 1.007 - 2.834，p = 0.047；OR : 3.442，95%CI: 2.202 - 5.382，p < 0.001），而风湿免疫疾病史与CP/CPPS样症状的发展密切相关（OR : 2.002，95%CI: 1.008 - 4.058，p = 0.048）。
确定了与CP/CPPS样症状发生和发展易感性相关的感染/炎症/免疫相关疾病、新的饮食习惯和生活方式。改变这些不规律情况是治疗CP/CPPS样症状患者的潜在策略。
