Reproductive Endocrinology and Infertility Division, Department of Obstetrics and Gynecology, Baylor College of Medicine. One Baylor Plaza, Houston 77030, TX, USA; Family Fertility Center, Texas Children's Hospital, Houston 77030, TX, USA.
Reproductive Endocrinology and Infertility Division, Department of Obstetrics and Gynecology, Baylor College of Medicine. One Baylor Plaza, Houston 77030, TX, USA; Family Fertility Center, Texas Children's Hospital, Houston 77030, TX, USA.
Steroids. 2022 Apr;180:108989. doi: 10.1016/j.steroids.2022.108989. Epub 2022 Feb 18.
Polycystic ovary syndrome (PCOS) is the most common ovulatory disorder in the world and is associated with multiple adverse outcomes. The phenotype is widely varied, with several pathologies contributing to the spectrum of the disease including insulin resistance, obesity and hyperandrogenemia. Of these, the role of hyperandrogenemia and the mechanism by which it causes dysfunction remains poorly understood. Early studies have shown that androgens may affect the metabolic pathways of a cell, and this may pose hazards at the level of the mitochondria. As mitochondria are strictly maternally inherited, this would provide an exciting explanation not only to the pathophysiology of PCOS as a disease, but also to the inheritance pattern. This review seeks to summarize what is known about PCOS and associated adverse outcomes with focus on the role of hyperandrogenemia and specific emphasis on the oocyte.
多囊卵巢综合征（PCOS）是世界上最常见的排卵障碍，与多种不良后果相关。其表型广泛多样，多种病理学与之相关，包括胰岛素抵抗、肥胖和高雄激素血症。其中，高雄激素血症的作用及其导致功能障碍的机制仍知之甚少。早期研究表明，雄激素可能会影响细胞的代谢途径，这可能会对线粒体水平造成危害。由于线粒体是严格母系遗传的，这不仅为 PCOS 作为一种疾病的病理生理学提供了一个令人兴奋的解释，也为遗传模式提供了一个解释。本文综述了目前已知的与 PCOS 相关的不良后果，重点关注高雄激素血症的作用，并特别强调卵母细胞。
