Ronai Z, Shaham J, Stein J, Sulitzeanu D
Cancer Immunol Immunother. 1986;22(1):72-5. doi: 10.1007/BF00205720.
A polyethylene glycol precipitation technique was used to determine the levels of circulating immune complexes (CIC) in breast cancer and melanoma patients. All patients in the study had undergone surgery and were free of distant metastatic disease. CIC were measured at two to four time intervals, of 3 to 6 months each, over an average follow-up period of 13.5 months (range 7-20 months). In both groups of patients, metastatic disease developed with a higher frequency in patients who had undetectable CIC levels throughout the follow-up period or had become negative at the time metastases were discovered.
采用聚乙二醇沉淀技术测定乳腺癌和黑色素瘤患者循环免疫复合物（CIC）水平。该研究中的所有患者均已接受手术且无远处转移性疾病。在平均13.5个月（范围7 - 20个月）的随访期内，每隔3至6个月在两到四个时间点测量CIC。在两组患者中，在整个随访期内CIC水平检测不到或在发现转移时变为阴性的患者发生转移性疾病的频率更高。
