Division of Endocrinology, Department of Internal Medicine, Seoul Metropolitan Government Boramae Medical Center, Seoul National University College of Medicine, Seoul, Republic of Korea.
Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
Clin Gastroenterol Hepatol. 2023 Apr;21(4):1105-1107.e3. doi: 10.1016/j.cgh.2022.02.026. Epub 2022 Feb 18.
The PNPLA3 rs738409 G allele increases the risk of not only nonalcoholic fatty liver disease (NAFLD) but also nonalcoholic steatohepatitis (NASH) or fibrosis. It also affects the prognosis of patients with NAFLD in specific conditions. After liver transplantation, patients with NAFLD carrying the rs738409 GG genotype have a higher risk of graft steatosis or development of hepatocellular carcinoma. In addition, rs738409 modifies the effects of medical intervention: patients with NAFLD carrying the GG genotype showed a lower effect of omega-3 polyunsaturated fatty acid treatment on the reduction of liver fat; in contrast, they were more sensitive to the beneficial effects of lifestyle modifications..
载脂蛋白 L3（PNPLA3）rs738409 的 G 等位基因不仅增加非酒精性脂肪性肝病（NAFLD）的风险，而且增加非酒精性脂肪性肝炎（NASH）或纤维化的风险。它还会影响特定条件下 NAFLD 患者的预后。肝移植后，携带 rs738409 GG 基因型的 NAFLD 患者发生移植物脂肪变性或肝细胞癌的风险更高。此外，rs738409 会改变医学干预的效果：携带 GG 基因型的 NAFLD 患者接受ω-3 多不饱和脂肪酸治疗降低肝脂肪的效果较低；相反，他们对生活方式改变的有益效果更为敏感。
