褪黑素缺乏会导致脆性X综合征患者生殖器增大吗？
Does melatonin deficiency cause the enlarged genitalia of the fragile-X syndrome?
作者信息
O'Hare J P, O'Brien I A, Arendt J, Astley P, Ratcliffe W, Andrews H, Walters R, Corrall R J
出版信息
Clin Endocrinol (Oxf). 1986 Mar;24(3):327-33. doi: 10.1111/j.1365-2265.1986.tb03274.x.
Abstract
Melatonin profiles were studied in five males with cytogenetic and clinical features of the fragile-X syndrome including megalo-orchidia and macrogenitosomia. In comparison with age-matched normal controls, the fragile-X group showed lower melatonin values and a significant impairment of the nocturnal rise in this hormone. Melatonin deficiency may thus be responsible for some of the phenotypic features of this disorder.
摘要
对五名患有脆性X综合征细胞遗传学和临床特征（包括巨睾症和巨大生殖器）的男性进行了褪黑素水平研究。与年龄匹配的正常对照组相比，脆性X组的褪黑素值较低，且该激素的夜间升高存在显著受损。因此，褪黑素缺乏可能是该疾病某些表型特征的原因。
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