Mzail A H, Noble A R
Clin Exp Pharmacol Physiol. 1986 Feb;13(2):131-8. doi: 10.1111/j.1440-1681.1986.tb00326.x.
The response of plasma levels of active and inactive renin to haemorrhage was investigated in sheep with indwelling artery and vein catheters. In conscious animals, loss of 10% of estimated blood volume over a 5 min period increased plasma active renin by a mean of 59%, a surprisingly small change. Plasma inactive renin also increased, but only by 86%. Maximum increases in both forms of renin occurred within 1 h of the haemorrhage. The effects of an equivalent blood loss were investigated in pentobarbitone-anaesthetized sheep maintained in an upright posture using padded slings. Anaesthesia per se had no effect on plasma active or inactive renin. In anaesthetized sheep, 3 h after haemorrhage, plasma active renin had increased by 403% and inactive renin by 299% above control values, but a plateau (maximum) response was not reached during this time. In both conscious and anaesthetized animals the haemorrhage-induced increases in active and inactive renin occurred in parallel. It appears that haemorrhage of this intensity is a comparatively mild stimulus to increase plasma renin concentration in conscious sheep but is much more effective in anaesthetized animals. This may be linked to anaesthetic-induced increases in prostaglandin synthesis within the kidney.
利用留置的动脉和静脉导管，在绵羊身上研究了活性和非活性肾素的血浆水平对出血的反应。在清醒动物中，5分钟内估计血容量损失10%，血浆活性肾素平均增加59%，变化小得出奇。血浆非活性肾素也增加，但仅增加86%。两种形式的肾素在出血后1小时内达到最大增加。在使用软垫吊床保持直立姿势的戊巴比妥麻醉绵羊中，研究了等量失血的影响。麻醉本身对血浆活性或非活性肾素没有影响。在麻醉绵羊中，出血3小时后，血浆活性肾素比对照值增加了403%，非活性肾素增加了299%，但在此期间未达到平台（最大）反应。在清醒和麻醉动物中，出血诱导的活性和非活性肾素增加是平行发生的。看来这种强度的出血对清醒绵羊血浆肾素浓度增加是一种相对温和的刺激，但在麻醉动物中更有效。这可能与麻醉诱导的肾脏内前列腺素合成增加有关。
