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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Richards H K, Grace S A, Noble A R, Munday K A

Clin Sci (Lond). 1979 Feb;56(2):105-8. doi: 10.1042/cs0560105.

Renin activity in rabbit plasma increases after acidification (pH 3.3), probably due to activation of an inactive form of renin. 2. Both active and inactive renin in plasma increase after haemorrhage. This stimulus does not change the relative proportions of the two forms. 3. After ligation of the renal blood vessels neither form of renin increases in response to haemorrhage. 4. One day after bilateral nephrectomy no inactive renin could be demonstrated in plasma. 5. In the rabbit, therefore, the kidney is a major source of the inactive renin in plasma.

兔血浆中的肾素活性在酸化（pH 3.3）后升高，可能是由于无活性形式的肾素被激活。2. 出血后血浆中的活性肾素和无活性肾素均增加。这种刺激不会改变两种形式的相对比例。3. 结扎肾血管后，两种形式的肾素均不会因出血而增加。4. 双侧肾切除术后一天，血浆中无法检测到无活性肾素。5. 因此，在兔中，肾脏是血浆中无活性肾素的主要来源。

Richards H K, Grace S A, Noble A R, Munday K A

Clin Sci (Lond). 1979 Feb;56(2):105-8. doi: 10.1042/cs0560105.

Renin activity in rabbit plasma increases after acidification (pH 3.3), probably due to activation of an inactive form of renin. 2. Both active and inactive renin in plasma increase after haemorrhage. This stimulus does not change the relative proportions of the two forms. 3. After ligation of the renal blood vessels neither form of renin increases in response to haemorrhage. 4. One day after bilateral nephrectomy no inactive renin could be demonstrated in plasma. 5. In the rabbit, therefore, the kidney is a major source of the inactive renin in plasma.

兔血浆中的肾素活性在酸化（pH 3.3）后升高，可能是由于无活性形式的肾素被激活。2. 出血后血浆中的活性肾素和无活性肾素均增加。这种刺激不会改变两种形式的相对比例。3. 结扎肾血管后，两种形式的肾素均不会因出血而增加。4. 双侧肾切除术后一天，血浆中无法检测到无活性肾素。5. 因此，在兔中，肾脏是血浆中无活性肾素的主要来源。