Department of Pediatrics, Fu Jen Catholic University Hospital, Fu Jen Catholic University, New Taipei City, Taiwan.
School of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan.
Sci Rep. 2022 Feb 21;12(1):2884. doi: 10.1038/s41598-022-06951-9.
Prenatal oxidative balance might influence cord blood IgE (cIgE) levels. We aimed to explore if certain prenatal dietary sources of antioxidants and pro-oxidants are associated with cIgE elevation and if they interact with IL4 and IL13 pathway genes. A structured questionnaire was completed during the third trimester of pregnancy for 1107 full-term newborns. Surveyed antioxidant-enriched food included fish, shellfish, and fruit, whereas surveyed pro-oxidant-contained food included fried fish sticks and canned fish. Cord blood was collected for measuring cIgE levels and genotyping IL13 rs1800925, rs20541, rs848, IL4 rs2243250, and STAT6 rs324011. Fairly lean fish consumption showed protection against cIgE elevation (odds ratio [OR] 0.66; 95% CI 0.49-0.90) in the whole sample, while daily fruit (OR 0.46; 95% CI 0.27-0.79) and ≥ monthly canned fish (OR 2.81; 95% CI 1.24-6.36) exhibited associations only in genetically susceptible babies. A prenatal food protective index, comprising any fairly lean fish, daily fruit, and the absence of any canned fish, exerted dose-response protection against cIgE elevation in babies carrying the IL13 rs20541 GA or AA genotype (P for trend < 0.0001; P for interaction = 0.004). We concluded that prenatal antioxidant-enriched and pro-oxidant-contained food consumption may influence cIgE, especially in genetically susceptible babies.
产前氧化平衡可能会影响脐血 IgE（cIgE）水平。我们旨在探索某些产前抗氧化剂和促氧化剂的饮食来源是否与 cIgE 升高有关，以及它们是否与 IL4 和 IL13 途径基因相互作用。在 1107 名足月新生儿的妊娠晚期，我们完成了一份结构化问卷。调查中富含抗氧化剂的食物包括鱼、贝类和水果，而调查中含促氧化剂的食物包括炸鱼条和罐装鱼。采集脐血以测量 cIgE 水平，并对 IL13 rs1800925、rs20541、rs848、IL4 rs2243250 和 STAT6 rs324011 进行基因分型。在整个样本中，适度食用瘦鱼可预防 cIgE 升高（比值比 [OR] 0.66；95%CI 0.49-0.90），而每天食用水果（OR 0.46；95%CI 0.27-0.79）和每月至少食用一次罐装鱼（OR 2.81；95%CI 1.24-6.36）仅在遗传易感婴儿中存在相关性。一个产前食物保护指数，包括任何适度食用的鱼、每天食用的水果和不食用任何罐装鱼，在携带 IL13 rs20541 GA 或 AA 基因型的婴儿中，对 cIgE 升高具有剂量反应保护作用（趋势检验 P<0.0001；交互作用检验 P=0.004）。我们得出结论，产前富含抗氧化剂和含促氧化剂的食物的摄入可能会影响 cIgE，尤其是在遗传易感婴儿中。
