Division of Chronic Disease Research Across the Lifecourse (CoRAL), Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Mass.
Division of Chronic Disease Research Across the Lifecourse (CoRAL), Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Mass.
J Allergy Clin Immunol. 2019 Dec;144(6):1534-1541.e5. doi: 10.1016/j.jaci.2019.07.044. Epub 2019 Aug 19.
Fetal oxidative balance (achieved when protective prenatal factors counteract sources of oxidative stress) might be critical for preventing asthma and allergic disease.
We examined prenatal intakes of hypothesized protective nutrients (including antioxidants) in conjunction with potential sources of oxidative stress in models of adolescent asthma and allergic disease.
We used data from 996 mother-child pairs in Project Viva. Exposures of interest were maternal prepregnancy body mass index and prenatal nutrients (energy-adjusted intakes of vitamins D, C, and E; β-carotene; folate; choline; and n-3 and n-6 polyunsaturated fatty acids [PUFAs]), air pollutant exposures (residence-specific third-trimester black carbon or particulate matter with a diameter of less than 2.5 μm [PM]), acetaminophen, and smoking. Outcomes were offspring's current asthma, allergic rhinitis, and allergen sensitization at a median age of 12.9 years. We performed logistic regression. Continuous exposures were log-transformed and modeled as z scores.
We observed protective associations for vitamin D (odds ratio [OR], 0.69 [95% CI, 0.53-0.89] for allergic rhinitis), the sum of the n-3 PUFAs eicosapentaenoic acid and docosahexaenoic acid (OR, 0.81 [95% CI, 0.66-0.99] for current asthma), and the n-3 PUFA α-linolenic acid (OR, 0.78 [95% CI, 0.64-0.95] for allergen sensitization and OR, 0.80 [95% CI 0.65-0.99] for current asthma). Black carbon and PM were associated with an approximately 30% increased risk for allergen sensitization. No multiplicative interactions were observed for protective nutrient intakes with sources of oxidative stress.
We identified potential protective prenatal nutrients (vitamin D and n-3 PUFAs), as well as adverse prenatal pro-oxidant exposures that might alter the risk of asthma and allergic disease into adolescence.
胎儿氧化平衡（当保护胎儿的因素抵消氧化应激源时达到）可能对预防哮喘和过敏性疾病至关重要。
我们研究了青少年哮喘和过敏性疾病模型中假设的保护性营养素（包括抗氧化剂）的产前摄入量以及潜在的氧化应激源。
我们使用了 Viva 项目中的 996 对母婴数据。感兴趣的暴露因素包括母亲孕前体重指数和产前营养素（维生素 D、C 和 E 的能量调整摄入量；β-胡萝卜素；叶酸；胆碱；以及 n-3 和 n-6 多不饱和脂肪酸 [PUFA]）、空气污染物暴露（特定居住地的妊娠晚期黑碳或直径小于 2.5μm 的颗粒物 [PM]）、对乙酰氨基酚和吸烟。结果是子女在 12.9 岁时的当前哮喘、过敏性鼻炎和过敏原致敏情况。我们进行了逻辑回归。连续暴露因素经对数转换并以 z 分数表示。
我们观察到维生素 D（比值比 [OR]，0.69 [95%置信区间，0.53-0.89] 对于过敏性鼻炎）、n-3PUFA 二十碳五烯酸和二十二碳六烯酸之和（OR，0.81 [95%置信区间，0.66-0.99] 对于当前哮喘）和 n-3PUFA α-亚麻酸（OR，0.78 [95%置信区间，0.64-0.95] 对于过敏原致敏和 OR，0.80 [95%置信区间，0.65-0.99] 对于当前哮喘）有保护作用。黑碳和 PM 与过敏原致敏的风险增加约 30%相关。未观察到保护性营养素摄入与氧化应激源之间的乘法相互作用。
我们确定了潜在的保护性产前营养素（维生素 D 和 n-3PUFA），以及可能改变青少年哮喘和过敏性疾病风险的不利产前促氧化剂暴露。
