Department of Public Health, Debre Markos University, P.O. Box 269, Debre Markos, Ethiopia.
Department of Human Nutrition, Debre Markos University, P.O. Box 269, Debre Markos, Ethiopia.
Sci Rep. 2022 Feb 21;12(1):2916. doi: 10.1038/s41598-022-07049-y.
Antiretroviral therapy lowers viral load only when people living with HIV maintain their treatment retention. Lost to follow-up is the persistent major challenge to the success of ART program in low-resource settings including Ethiopia. The purpose of this study is to estimate time to lost to follow-up and its predictors in antiretroviral therapies amongst adult patients. Among registered HIV patients, 542 samples were included. Data cleaning and analysis were done using Stata/SE version 14 software. In multivariable Cox regression, a p-value < 0.05 at 95% confidence interval with corresponding adjusted hazards ratio (AHR) were statistically significant predictors. In this study, the median time to lost to follow-up is 77 months. The incidence density of lost to follow-up was 13.45 (95% CI: 11.78, 15.34) per 100 person-years. Antiretroviral therapy drug adherence [AHR: 3.04 (95% CI: 2.18, 4.24)], last functional status [AHR: 2.74 (95% CI: 2.04, 3.67)], and INH prophylaxis [AHR: 1.65 (95% CI: 1.07, 2.56) were significant predictors for time to lost to follow-up. The median time to lost was 77 months and incidence of lost to follow-up was high. Health care providers should be focused on HIV counseling and proper case management focused on identified risks.
抗逆转录病毒疗法只有在艾滋病毒感染者保持治疗保留率的情况下才能降低病毒载量。失访是包括埃塞俄比亚在内的资源匮乏环境中抗逆转录病毒治疗项目取得成功的持续主要挑战。本研究旨在估计成人患者接受抗逆转录病毒治疗后失访的时间及其预测因素。在登记的艾滋病毒患者中，纳入了 542 个样本。使用 Stata/SE 版本 14 软件进行数据清理和分析。在多变量 Cox 回归中，95%置信区间内 p 值<0.05 且对应的校正风险比（AHR）具有统计学意义的预测因素。在这项研究中，失访的中位时间为 77 个月。失访的发生率密度为 13.45（95%CI：11.78，15.34）每 100 人年。抗逆转录病毒治疗药物依从性[AHR：3.04（95%CI：2.18，4.24）]、最后功能状态[AHR：2.74（95%CI：2.04，3.67）]和 INH 预防[AHR：1.65（95%CI：1.07，2.56）]是失访时间的显著预测因素。失访的中位时间为 77 个月，失访的发生率较高。卫生保健提供者应专注于艾滋病毒咨询和针对确定风险的适当病例管理。
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