Dentistry Graduate Program, Faculty of Dentistry, Universidade Federal de Goiás (UFG), Goiânia, Goiás, Brazil.
Department of Paediatric Dentistry, Faculty of Dentistry, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil.
Sci Rep. 2022 Feb 21;12(1):2862. doi: 10.1038/s41598-022-06993-z.
The Analgesia Nociception Index (ANI), an objective measure of pain based on heart rate variability (HRV), has its usefulness in awake patients still unclear. This systematic review and meta-analysis aimed to assess ANI's accuracy compared to self-reported pain measures in conscious individuals undergoing medical procedures or painful stimuli. PubMed, Ovid, Web of Science, Scopus, Embase, and grey literature were searched until March 2021. Of the 832 identified citations, 16 studies complied with the eligibility criteria. A meta-analysis including nine studies demonstrated a weak negative correlation between ANI and NRS for pain assessment in individuals in the post-anesthetic recovery room (r = - 0.0984, 95% CI = - 0.397 to 0.220, I = 95.82%), or in those submitted to electrical stimulus (r = - 0.089; 95% CI = - 0.390 to 0.228, I = 0%). The evidence to use ANI in conscious individuals is weak compared to self-report measures of pain, yet ANI explains a part of self-report. Therefore, some individuals may be benefited from the use of ANI during procedures or in the immediate postoperative period.
镇痛伤害指数（ANI）是一种基于心率变异性（HRV）的客观疼痛测量方法，其在清醒患者中的应用尚不清楚。本系统评价和荟萃分析旨在评估 ANI 在接受医学程序或疼痛刺激的清醒个体中与自我报告疼痛测量相比的准确性。我们检索了 PubMed、Ovid、Web of Science、Scopus、Embase 和灰色文献，截至 2021 年 3 月。在 832 篇鉴定的引文当中，有 16 项研究符合纳入标准。包括 9 项研究的荟萃分析表明，ANI 与术后恢复室个体的 NRS 疼痛评估之间存在弱负相关（r = -0.0984，95%CI = -0.397 至 0.220，I = 95.82%），或与接受电刺激的个体之间存在弱负相关（r = -0.089；95%CI = -0.390 至 0.228，I = 0%）。与自我报告的疼痛测量相比，ANI 用于清醒个体的证据较弱，但 ANI 解释了自我报告的一部分。因此，一些个体可能会受益于在程序期间或术后即刻使用 ANI。
