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碳酸钙纳米晶体控释后石榴皮提取物的生物活性增强

Enhanced Bioactivity of Pomegranate Peel Extract following Controlled Release from CaCO Nanocrystals.

作者信息

Baldassarre Francesca, Vergaro Viviana, De Castro Federica, Biondo Francesca, Suranna Gian Paolo, Papadia Paride, Fanizzi Francesco P, Rongai Domenico, Ciccarella Giuseppe

机构信息

Department of Biological and Environmental Sciences, UdR INSTM of Lecce University of Salento, Via Monteroni, 73100 Lecce, Italy.

Institute of Nanotechnology, CNR NANOTEC, Consiglio Nazionale Delle Ricerche, Via Monteroni, 73100 Lecce, Italy.

出版信息

Bioinorg Chem Appl. 2022 Feb 12;2022:6341298. doi: 10.1155/2022/6341298. eCollection 2022.

DOI:10.1155/2022/6341298
PMID:35190732
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8858070/
Abstract

Pomegranate peel extract is rich of interesting bioactive chemicals, principally phenolic compounds, which have shown antimicrobial, anticancer, and antioxidative properties. The aim of this work was to improve extract' bioactivity through the adsorption on calcium carbonate nanocrystals. Nanocrystals revealed as efficient tools for extract adsorption reaching 50% of loading efficiency. Controlled release of the contained metabolites under acidic pH has been found, as it was confirmed by quantitative assay and qualitative study through NMR analysis. Specific functionality of inorganic nanocarriers could be also tuned by biopolymeric coating. The resulting coated nanoformulations showed a great antimicrobial activity against fungus preventing strawberries disease better than a commercial fungicide. Furthermore, nanoformulations demonstrated a good antiproliferative activity in neuroblastoma and breast cancer cells carrying out a higher cytotoxic effect respect to free extract, confirming a crucial role of nanocarriers. Finally, pomegranate peel extract showed a very high radical scavenging ability, equal to ascorbic acid. Antioxidant activity, measured also in intracellular environment, highlighted a protective action of extract-adsorbed nanocrystals twice than free extract, providing a possible application for new nutraceutical formulations.

摘要

石榴皮提取物富含多种有趣的生物活性化合物，主要是酚类化合物，这些化合物已显示出抗菌、抗癌和抗氧化特性。这项工作的目的是通过碳酸钙纳米晶体吸附来提高提取物的生物活性。纳米晶体被证明是提取物吸附的有效工具，负载效率达到50%。通过酸性pH下所含代谢物的控释研究发现，定量分析和核磁共振分析的定性研究证实了这一点。无机纳米载体的特定功能也可以通过生物聚合物涂层来调节。所得的包衣纳米制剂对真菌显示出很强的抗菌活性，比市售杀菌剂更能有效预防草莓病害。此外，纳米制剂在神经母细胞瘤和乳腺癌细胞中表现出良好的抗增殖活性，相对于游离提取物具有更高的细胞毒性作用，证实了纳米载体的关键作用。最后，石榴皮提取物表现出非常高的自由基清除能力，与抗坏血酸相当。在细胞内环境中测得的抗氧化活性突出了吸附提取物的纳米晶体的保护作用是游离提取物的两倍，为新型营养制剂提供了可能的应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db5e/8858070/b99226b9c84e/BCA2022-6341298.009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db5e/8858070/6265dc55d2b8/BCA2022-6341298.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db5e/8858070/8719054f3f67/BCA2022-6341298.002.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db5e/8858070/760c2afc434c/BCA2022-6341298.005.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db5e/8858070/e99fa5b31e2a/BCA2022-6341298.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db5e/8858070/26636d565005/BCA2022-6341298.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db5e/8858070/b99226b9c84e/BCA2022-6341298.009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db5e/8858070/6265dc55d2b8/BCA2022-6341298.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db5e/8858070/8719054f3f67/BCA2022-6341298.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db5e/8858070/71b1d7d547f5/BCA2022-6341298.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db5e/8858070/cb6abf2cf6dc/BCA2022-6341298.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db5e/8858070/760c2afc434c/BCA2022-6341298.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db5e/8858070/b9e3886ddbf9/BCA2022-6341298.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db5e/8858070/e99fa5b31e2a/BCA2022-6341298.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db5e/8858070/26636d565005/BCA2022-6341298.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db5e/8858070/b99226b9c84e/BCA2022-6341298.009.jpg

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