Ke Cai-Ling, Deng Fu-Sheng, Chuang Chih-Yu, Lin Ching-Hsuan
Department of Biochemical Science and Technology, College of Life Science, National Taiwan University, Taipei 10617, Taiwan.
Polymers (Basel). 2021 Mar 15;13(6):904. doi: 10.3390/polym13060904.
Chitosan is a naturally originating product that can be applied in many areas due to its biocompatibility, biodegradability, and nontoxic properties. The broad-spectrum antimicrobial activity of chitosan offers great commercial potential for this product. Nevertheless, the antimicrobial activity of chitosan varies, because this activity is associated with its physicochemical characteristics and depends on the type of microorganism. In this review article, the fundamental properties, modes of antimicrobial action, and antimicrobial effects-related factors of chitosan are discussed. We further summarize how microorganisms genetically respond to chitosan. Finally, applications of chitosan-based biomaterials, such as nanoparticles and films, in combination with current clinical antibiotics or antifungal drugs, are also addressed.
壳聚糖是一种天然产物，因其生物相容性、生物可降解性和无毒特性而可应用于许多领域。壳聚糖的广谱抗菌活性为该产品提供了巨大的商业潜力。然而，壳聚糖的抗菌活性各不相同，因为这种活性与其物理化学特性相关，并取决于微生物的类型。在这篇综述文章中，讨论了壳聚糖的基本特性、抗菌作用模式以及与抗菌效果相关的因素。我们进一步总结了微生物对壳聚糖的基因反应。最后，还介绍了基于壳聚糖的生物材料，如纳米颗粒和薄膜，与目前临床使用的抗生素或抗真菌药物联合使用的情况。
