Gupta Priti, Hodgman Charles F, Schadler Keri L, LaVoy Emily C
Department of Health and Human Performance, The University of Houston, 3875 Holman St., Rm 104 Garrison, Houston, TX, 77204-6015, USA.
Department of Pediatrics, MD Anderson Cancer Center, Houston, TX, USA.
Support Care Cancer. 2022 Jul;30(7):5669-5690. doi: 10.1007/s00520-022-06925-7. Epub 2022 Feb 21.
Exercise can lower the risk of developing pancreatic cancer and has the potential to improve physical fitness and quality of life in patients with the disease. Yet, the effects of exercise training during pancreatic cancer treatment remain poorly characterized. This hampers the development of evidence-based disease-specific exercise recommendations.
The purpose of this review was to describe and interpret the effect of exercise on physiological, QoL, and cancer-specific outcomes reported in clinical trials among pancreatic cancer patients during treatment.
We conducted a scoping review of the literature according to the framework proposed by Arksey and O'Malley. Articles published prior to December 2021 were retrieved from PubMed, EMBASE, and Scopus. We only included studies that prescribed structured cardiorespiratory and/or resistance exercise in pancreatic cancer patients undergoing treatment.
A total of 662 references were retrieved, of which 24 are included in the review. Twelve articles were randomized controlled trials and 12 were single-arm trials. Overlap in the trials from which data were reported occurred in 16 articles. Moderate intensity exercise was most commonly prescribed, reported feasible for most patients, with potential to enhance physical fitness and QoL. However, exercise adherence and beneficial effects may diminish with disease progression. Limited evidence suggests exercise may benefit cancer-specific outcomes.
The results of this review indicate that exercise is feasible during pancreatic cancer treatment. Exercise can also improve physical fitness and QoL. However, its beneficial effects may fall with advanced disease and more rigorous research is needed to develop precise exercise protocols for this population.
运动可以降低患胰腺癌的风险，并且有可能改善该疾病患者的身体素质和生活质量。然而，胰腺癌治疗期间运动训练的效果仍未得到充分描述。这阻碍了基于证据的针对该疾病的运动建议的制定。
本综述的目的是描述和解释运动对胰腺癌患者治疗期间临床试验中报告的生理、生活质量和癌症特异性结局的影响。
我们根据阿克西和奥马利提出的框架对文献进行了范围综述。从PubMed、EMBASE和Scopus检索了2021年12月之前发表的文章。我们仅纳入了对正在接受治疗的胰腺癌患者规定进行结构化心肺和/或阻力运动的研究。
共检索到662篇参考文献，其中24篇纳入本综述。12篇文章为随机对照试验，12篇为单臂试验。16篇文章报告的数据来自重叠的试验。中等强度运动是最常规定的，对大多数患者来说可行，有可能提高身体素质和生活质量。然而，运动依从性和有益效果可能会随着疾病进展而降低。有限的证据表明运动可能有益于癌症特异性结局。
本综述结果表明，运动在胰腺癌治疗期间是可行的。运动还可以改善身体素质和生活质量。然而，其有益效果可能会随着疾病进展而降低，需要更严格的研究来为该人群制定精确的运动方案。
