Jee Hyunseok
School of Kinesiology, Yeungnam University, Gyeongsan, Gyeongbuk, South Korea.
Cancer Med. 2025 Apr;14(7):e70848. doi: 10.1002/cam4.70848.
Utilizing data from the National Health Insurance Sharing Service database, this study explored significant risk factors for pancreatic cancer in a cohort of 1,120,377 South Korean individuals over a 10-year period (2009-2019).
Propensity score matching was employed to ensure comparability between 3535 pancreatic cancer patients and a control group with a common cold diagnosis. The study analyzed various lifestyle factors and biochemical markers, including smoking status, alcohol consumption, fasting blood glucose (FBS) levels, liver enzyme levels, and Charlson comorbidity index (CCI) scores.
The findings revealed that current smoking, frequent alcohol consumption, and elevated levels of FBS and liver enzymes were associated with an increased risk of pancreatic cancer. Conversely, engaging in high-intensity exercise (≥ 20 min, twice weekly) was correlated with a 20% reduction in pancreatic cancer risk (p < 0.05). Additionally, optimal thresholds for total cholesterol (179.50 mg/dL), GGT (29.50 U/L), low-density lipoprotein cholesterol (104.50 mg/dL), and CCI score (2.50) were identified, which may facilitate early diagnosis and intervention.
These findings underscore the importance of modifiable lifestyle factors in managing pancreatic cancer risk and highlight the potential of personalized, evidence-based interventions-such as high-intensity exercise programs-in improving prevention and treatment outcomes.
本研究利用国民健康保险共享服务数据库的数据，在10年期间（2009 - 2019年）对1120377名韩国个体组成的队列进行研究，以探索胰腺癌的显著危险因素。
采用倾向得分匹配法，确保3535例胰腺癌患者与诊断为普通感冒的对照组具有可比性。该研究分析了各种生活方式因素和生化指标，包括吸烟状况、饮酒情况、空腹血糖（FBS）水平、肝酶水平和查尔森合并症指数（CCI）评分。
研究结果显示，当前吸烟、频繁饮酒以及FBS和肝酶水平升高与胰腺癌风险增加有关。相反，进行高强度运动（≥20分钟，每周两次）与胰腺癌风险降低20%相关（p < 0.05）。此外，还确定了总胆固醇（179.50mg/dL）、γ-谷氨酰转移酶（GGT，29.50U/L）、低密度脂蛋白胆固醇（104.50mg/dL）和CCI评分（2.50）的最佳阈值，这可能有助于早期诊断和干预。
这些发现强调了可改变的生活方式因素在控制胰腺癌风险中的重要性，并突出了个性化、基于证据的干预措施（如高强度运动计划）在改善预防和治疗效果方面的潜力。
