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治疗严重肢体缺血的新型疗法。

Novel Therapies for Critical Limb-Threatening Ischemia.

作者信息

Karimi Ashkan, Lauria Alexis L, Aryavand Behdad, Neville Richard F

机构信息

Carient Heart and Vascular, Manassas, VA, 20109, USA.

Walter Reed National Military Medical Center, Bethesda, MD, 20889, USA.

出版信息

Curr Cardiol Rep. 2022 May;24(5):513-517. doi: 10.1007/s11886-022-01669-6. Epub 2022 Feb 22.

DOI:10.1007/s11886-022-01669-6
PMID:35192129
Abstract

PURPOSE OF REVIEW

This review intends to discuss the latest endovascular and surgical advancement in the treatment of critical limb-threatening ischemia (CLTI).

RECENT FINDINGS

We discuss novel endovascular technological advancements such as intravascular lithotripsy, the Tack endovascular stent, the PQ Bypass DETOUR system, and the LimFlow System for deep venous arterialization (DVA) in the very high risk "no-option" CLTI population. We also discuss the increasing adoption of radial and pedal approaches for endovascular revascularization and the tibiopedal arterial minimally invasive (TAMI) technique. On the surgical front, we discuss the distal vein patch technique and surgical and hybrid DVA. Recent advancements in the treatment options of CLTI will likely lead to reducing the rate of major amputations if they are adopted in a collaborative environment in order to apply the most appropriate treatment option to each individual patient based on the anatomy, comorbidities, functional status, and local expertise.

摘要

综述目的

本综述旨在探讨治疗严重肢体缺血(CLTI)的最新血管内和外科进展。

最新发现

我们讨论了新型血管内技术进展,如血管内碎石术、Tack血管内支架、PQ旁路DETOUR系统以及用于极高风险“无选择”CLTI人群的LimFlow深静脉动脉化(DVA)系统。我们还讨论了血管内血运重建中桡动脉和足背动脉入路以及胫足动脉微创(TAMI)技术的应用增加情况。在外科方面,我们讨论了远端静脉补片技术以及外科和混合DVA。如果在协作环境中采用CLTI治疗选择的最新进展,以便根据每位患者的解剖结构、合并症、功能状态和当地专业知识应用最合适的治疗方案,可能会降低大截肢率。

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本文引用的文献

1
Twelve-Month Results of Tack-Optimized Balloon Angioplasty Using the Tack Endovascular System in Below-the-Knee Arteries (TOBA II BTK).使用Tack血管内系统对膝下动脉进行球囊血管成形术优化(TOBA II BTK)的12个月结果
J Endovasc Ther. 2020 Aug;27(4):626-636. doi: 10.1177/1526602820944402.
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Open, percutaneous, and hybrid deep venous arterialization technique for no-option foot salvage.开放式、经皮和杂交深静脉动脉化技术用于无选择的足部挽救。
J Vasc Surg. 2020 Jun;71(6):2152-2160. doi: 10.1016/j.jvs.2019.10.085. Epub 2019 Dec 31.
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Interim Results of the PROMISE I Trial to Investigate the LimFlow System of Percutaneous Deep Vein Arterialization for the Treatment of Critical Limb Ischemia.
碱性成纤维细胞生长因子转染的人胚胎干细胞源性周细胞样细胞移植促进严重慢性下肢缺血小鼠的血管生成恢复。
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用于治疗严重肢体缺血的经皮深静脉动脉化LimFlow系统的PROMISE I试验中期结果。
J Invasive Cardiol. 2019 Mar;31(3):57-63. doi: 10.25270/jic/18.00340.
4
Hybrid Foot Vein Arterialization in No-Option Patients With Critical Limb Ischemia: A Preliminary Report.杂交足静脉动脉化治疗无选择肢端缺血患者:初步报告。
J Endovasc Ther. 2019 Feb;26(1):7-17. doi: 10.1177/1526602818820792. Epub 2018 Dec 28.
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Nationwide Trends of Hospital Admission and Outcomes Among Critical Limb Ischemia Patients: From 2003-2011.全国范围内重症肢体缺血患者住院和结局的趋势:2003-2011 年。
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An expanded series of distal bypass using the distal vein patch technique to improve prosthetic graft performance in critical limb ischemia.采用远端静脉补片技术扩大远端旁路系列,改善临界肢体缺血患者人造移植物的性能。
Eur J Vasc Endovasc Surg. 2012 Aug;44(2):177-82. doi: 10.1016/j.ejvs.2012.04.014. Epub 2012 May 15.
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Deep calf veins arterialization for inferior limb preservation in diabetic patients with extended ischaemic wounds, unfit for direct arterial reconstruction: preliminary results according to an angiosome model of perfusion.在患有广泛缺血性伤口、不适合直接动脉重建的糖尿病患者中,采用小腿深静脉动脉化来保留下肢:基于血管体灌注模型的初步结果
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Distal vein patch with an arteriovenous fistula: a viable option for the patient without autogenous conduit and severe distal occlusive disease.带动静脉内瘘的远端静脉补片:对于没有自体血管且存在严重远端闭塞性疾病的患者来说是一种可行的选择。
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