J Pediatr Ophthalmol Strabismus. 2022 Sep-Oct;59(5):320-325. doi: 10.3928/01913913-20220103-01. Epub 2022 Feb 22.
To examine the choroidal structure in children with anisometropic amblyopia using the binarization method.
Thirty children with unilateral anisometropic amblyopia and 30 healthy age- and sex-matched controls were included in the study. Choroidal thickness was measured with optical coherence tomography. The choroidal layer was examined with the binarization method using ImageJ software (National Institutes of Health). The total choroidal area, stromal area, luminal area, luminal area to stromal area ratio, and choroidal vascular index were calculated. The values were compared by correlating the spherical equivalent (SE) (determined by an autorefractometer) with anterior chamber depth, axial length, central corneal thickness (measured by optical biometry), and choroidal thickness values.
Mean SE values were 3.75 ± 2.16 diopters (D) in the amblyopic eyes, 2.39 ± 2.09 D in the fellow eyes, and -0.27 ± 0.53 D in the control eyes. Best corrected visual acuity (BCVA) was 0.29 ± 0.11 logarithm of the minimum angle of resolution (logMAR) in the amblyopic eyes, 0.02 ± 0.04 logMAR in the fellow eyes, and 0 ± 0 logMAR in the control eyes. Choroidal thickness values were 351 ± 47 µm in the amblyopic eyes, 333 ± 55 µm in the fellow eyes, and 324 ± 51 µm in the control eyes. Luminal area to stromal area ratio values were 1.73 ± 0.13 in the amblyopic eyes, 1.76 ± 0.15 in the fellow eyes, and 2.02 ± 0.25 in the control eyes. Choroidal vascular index values were 63% ± 0.02 in the amblyopic eyes, 64% ± 0.02 in the fellow eyes, and 66% ± 0.03 in the control eyes. BCVA, SE, choroidal thickness, luminal area to stromal area ratio, and choroidal vascular index were significantly different in each group. The total choroidal area, luminal area, and stromal area were similar in all eyes. No correlation was found between choroidal vascular index and choroidal thickness, anterior chamber depth, axial length, and central corneal thickness.
In children with anisometropic amblyopia, the total choroidal area was relatively larger in both the amblyopic and the fellow eyes compared to the control eyes. Due to the higher stromal area and lower luminal area, both the amblyopic and the fellow eyes also had lower choroidal vascular index values than control eyes. .
使用二值化方法研究屈光参差性弱视儿童的脉络膜结构。
本研究纳入了 30 名单侧屈光参差性弱视儿童和 30 名年龄和性别匹配的健康对照组。使用光学相干断层扫描测量脉络膜厚度。使用 ImageJ 软件（美国国立卫生研究院）以二值化方法检查脉络膜层。计算总脉络膜面积、基质面积、管腔面积、管腔面积与基质面积比和脉络膜血管指数。通过比较等效球镜（由自动折射仪确定）与前房深度、眼轴长度、中央角膜厚度（通过光学生物测量法测量）和脉络膜厚度值，对这些值进行比较。
弱视眼的平均等效球镜值为 3.75 ± 2.16 屈光度（D），对侧眼为 2.39 ± 2.09 D，对照组为-0.27 ± 0.53 D。弱视眼最佳矫正视力（BCVA）为 0.29 ± 0.11 最小分辨角对数（logMAR），对侧眼为 0.02 ± 0.04 logMAR，对照组为 0 ± 0 logMAR。弱视眼的脉络膜厚度值为 351 ± 47 µm，对侧眼为 333 ± 55 µm，对照组为 324 ± 51 µm。弱视眼的管腔面积与基质面积比为 1.73 ± 0.13，对侧眼为 1.76 ± 0.15，对照组为 2.02 ± 0.25。弱视眼的脉络膜血管指数为 63% ± 0.02，对侧眼为 64% ± 0.02，对照组为 66% ± 0.03。BCVA、等效球镜、脉络膜厚度、管腔面积与基质面积比和脉络膜血管指数在各组间差异均有统计学意义。所有眼的总脉络膜面积、管腔面积和基质面积均相似。脉络膜血管指数与脉络膜厚度、前房深度、眼轴长度和中央角膜厚度之间无相关性。
在屈光参差性弱视儿童中，弱视眼和对侧眼的总脉络膜面积均大于对照组。由于基质面积较高，管腔面积较低，弱视眼和对侧眼的脉络膜血管指数也低于对照组。
