脂联素基因多态性与膝骨关节炎的相关性：荟萃分析。
Associations between adipokines gene polymorphisms and knee osteoarthritis: a meta-analysis.
机构信息
Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Hunan Key Laboratory of Joint Degeneration and Injury, Xiangya Hospital, Central South University, Changsha, China.
出版信息
BMC Musculoskelet Disord. 2022 Feb 22;23(1):166. doi: 10.1186/s12891-022-05111-4.
BACKGROUND
Adipokines gene polymorphisms are speculated to be associated with the risk of knee osteoarthritis (OA), but evidence remains conflicting. This study therefore aimed to examine whether associations exist between adipokines gene polymorphisms and knee OA by considering the evidence collected from eligible studies through a meta-analysis.
METHODS
A systematic search was performed on PubMed, Embase, Web of Science, China National Knowledge Infrastructure (CNKI), and Wanfang up to March 31, 2020. Meta-analysis was carried out by focusing on the associations between adipokines gene polymorphisms and knee OA with the allele model, dominant model, and recessive model.
RESULTS
The present meta-analysis included 5 eligible studies for ADIPOQ rs1501299 with 1,021 cases and 1,097 controls, 3 eligible studies for ADIPOQ rs2241766 with 549 cases and 544 controls, 3 eligible studies for LEPR rs1137101 with 808 cases and 856 controls, 2 eligible studies for VISFATIN rs4730153 with 339 cases and 680 controls and 2 eligible studies for VISFATIN rs16872158 with 339 cases and 680 controls. Significant association was observed between LEPR rs1137101 and knee OA in the overall population (recessive: OR = 0.40, 95% CI 0.21-0.79). Limited data revealed that associations may exist between ADIPOQ rs2241766 and knee OA in Asians (dominant: OR = 1.35, 95% CI 1.03-1.78), between VISFATIN rs4730153 and knee OA in Asians (allele: OR = 0.58, 95% CI 0.41-0.83; dominant: OR = 0.57, 95% CI 0.39-0.83), and between VISFATIN rs16872158 and knee OA in Asians (allele: OR = 1.84, 95% CI 1.26-2.68; dominant: OR = 1.94, 95% CI 1.31-2.89).
CONCLUSIONS
Adipokines gene polymorphisms may be associated with knee OA. The association was observed in LEPR rs1137101 in the present study. In addition, limited data revealed that associations may also exist in ADIPOQ rs2241766, VISFATIN rs4730153 and VISFATIN rs16872158.
PROSPERO REGISTRATION
CRD42020187664.
背景
脂肪因子基因多态性被推测与膝关节骨关节炎（OA）的风险相关，但证据仍存在争议。因此，本研究旨在通过荟萃分析，考虑从合格研究中收集的证据，来研究脂肪因子基因多态性与膝关节 OA 之间是否存在关联。
方法
系统检索了 PubMed、Embase、Web of Science、中国知网（CNKI）和万方数据库，检索时间截至 2020 年 3 月 31 日。通过等位基因模型、显性模型和隐性模型，重点关注脂肪因子基因多态性与膝关节 OA 之间的关联，进行荟萃分析。
结果
本荟萃分析纳入了 5 项 ADIPOQ rs1501299 的合格研究，共纳入 1021 例病例和 1097 例对照，3 项 ADIPOQ rs2241766 的合格研究，共纳入 549 例病例和 544 例对照，3 项 LEPR rs1137101 的合格研究，共纳入 808 例病例和 856 例对照，2 项 VISFATIN rs4730153 的合格研究，共纳入 339 例病例和 680 例对照，2 项 VISFATIN rs16872158 的合格研究，共纳入 339 例病例和 680 例对照。总体人群中 LEPR rs1137101 与膝关节 OA 之间存在显著关联（隐性：OR=0.40，95%CI 0.21-0.79）。有限的数据表明，ADIPOQ rs2241766 与亚洲人群膝关节 OA 之间可能存在关联（显性：OR=1.35，95%CI 1.03-1.78），VISFATIN rs4730153 与亚洲人群膝关节 OA 之间可能存在关联（等位基因：OR=0.58，95%CI 0.41-0.83；显性：OR=0.57，95%CI 0.39-0.83），VISFATIN rs16872158 与亚洲人群膝关节 OA 之间可能存在关联（等位基因：OR=1.84，95%CI 1.26-2.68；显性：OR=1.94，95%CI 1.31-2.89）。
结论
脂肪因子基因多态性可能与膝关节 OA 相关。本研究中观察到 LEPR rs1137101 与膝关节 OA 相关。此外，有限的数据表明，ADIPOQ rs2241766、VISFATIN rs4730153 和 VISFATIN rs16872158 也可能与膝关节 OA 相关。
PROSPERO 注册号：CRD42020187664。
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