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是什么使碳纳米颗粒成为生物应用的一种有效材料?

What makes carbon nanoparticle a potent material for biological application?

作者信息

Chatterjee Niranjan, Kumar Piyush, Kumar Krishan, Misra Santosh K

机构信息

Department of Biological Sciences & Bioengineering and The Mehta Family Centre for Engineering in Medicine, Indian Institute of Technology Kanpur, Kanpur, Uttar Pradesh, India.

出版信息

Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2022 May;14(3):e1782. doi: 10.1002/wnan.1782. Epub 2022 Feb 23.

Abstract

Carbon materials are generally utilized in the form of carbon allotropes and their characteristics are exploited as such or for improving the thermal, electrical, optical, and mechanical properties of other biomaterials. This has now found a broader share in conventional biomaterial space with the generation of nanodiamond, carbon dot, carbon nanoparticles (CNPs), and so forth. With properties of better biocompatibility, intrinsic optical emission, aqueous suspendability, and easier surface conjugation possibilities made CNPs as one of the fore most choice for biological applications especially for use in intracellular spaces. There are various reports available presenting methods of preparing, characterizing, and using CNPs for various biological applications but a collection of information on what makes CNP a suitable biomaterial to achieve those biological activities is yet to be provided in a significant way. Herein, a series of correlations among synthesis, characterization, and mode of utilization of CNP have been incorporated along with the variations in its use as agent for sensing, imaging, and therapy of different diseases or conditions. It is ensembled that how simplified and optimized methods of synthesis is correlated with specific characteristics of CNPs which were found to be suitable in the specific biological applications. These comparisons and correlations among various CNPs, will surely provide a platform to generate new edition of this nanomaterial with improvised applications and newer methods of evaluating structural, physical, and functional properties. This may ensure the eventual use of CNPs for human being for specific need in near future. This article is categorized under: Nanotechnology Approaches to Biology > Nanoscale Systems in Biology Diagnostic Tools > Biosensing Diagnostic Tools > In Vitro Nanoparticle-Based Sensing Therapeutic Approaches and Drug Discovery > Emerging Technologies.

摘要

碳材料通常以碳的同素异形体形式被利用,其特性被直接利用或用于改善其他生物材料的热、电、光和机械性能。随着纳米金刚石、碳点、碳纳米颗粒(CNPs)等的产生,这在传统生物材料领域中占据了更广泛的份额。由于具有更好的生物相容性、内在光发射、水悬浮性以及更易于表面偶联的可能性等特性,碳纳米颗粒成为生物应用的首选之一,尤其适用于细胞内空间。有各种报告介绍了制备、表征和将碳纳米颗粒用于各种生物应用的方法,但关于使碳纳米颗粒成为实现这些生物活性的合适生物材料的信息收集工作仍有待大力开展。在此,我们纳入了一系列关于碳纳米颗粒的合成、表征和利用方式之间的相关性,以及其作为不同疾病或病症的传感、成像和治疗剂使用时的变化情况。我们汇总了合成的简化和优化方法如何与碳纳米颗粒的特定特性相关联,而这些特性在特定生物应用中被发现是合适的。各种碳纳米颗粒之间的这些比较和相关性,肯定会提供一个平台,以产生具有改进应用以及评估结构、物理和功能特性的新方法的新型纳米材料。这可能确保在不久的将来碳纳米颗粒最终能满足人类的特定需求。本文分类如下:纳米技术在生物学中的应用>生物学中的纳米系统;诊断工具>生物传感诊断工具;治疗方法与药物发现>新兴技术。

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