通过磁共振成像的体素内不相干运动扩散加权成像检测强直性脊柱炎骶髂关节的疾病活动度。
Detection of the disease activity with ankylosing spondylitis through intravoxel incoherent motion diffusion-weighted MR imaging of sacroiliac joint.
机构信息
Department of Imaging, Linyi Central Hospital, Linyi, Shandong, China.
Department of Radiology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
出版信息
Br J Radiol. 2022 May 1;95(1133):20211074. doi: 10.1259/bjr.20211074. Epub 2022 Mar 24.
OBJECTIVE
To explore the value of the quantitative parameter of intravoxel incoherent motion diffusion (IVIM-DWI) at 3.0 T MRI of the sacroiliac joint in differentiating different disease activity statuses of ankylosing spondylitis (AS) and to compare it with traditional diffusion-weighted imaging (DWI) and Spondyloarthritis Research Consortium of Canada (SPARCC) score.
METHODS
56 AS patients (active group, inactive group) and 24 healthy controls were included. Clinical data, quantitative parameters of IVIM-DWI MR images and the SPARCC scores were collected. The Kruskal-Wallis test was used to compare the differences between the groups. Receiver operating characteristic (ROC) curve analysis of histogram data and the SPARCC scores identified the efficacy of the three groups. The Spearman correlation coefficients were used to analyse the correlation between the quantitative IVIIM-DWI parameters and the SPARCC score.
RESULTS
The f (10th percentile) and SPARCC score of the active group were significantly higher than those of the inactive group. The f (10th, 25th, 50th percentiles), D (average, entropy, 10th ~ 90 th percentiles), D (kurtosis, skewness), ADC (average, 10th ~ 90 th percentiles) and the SPARCC score of the active group were significantly higher than the control group ( 0.05). The AUC of the SPARCC score was the highest (0.799) in the identification between the active and inactive groups, and the sensitivity and specificity were 69.23 and 82.35%, respectively, at the cut-off value of 12. The SPARCC score was positively correlated with each percentile and the average value.
CONCLUSIONS
Quantitative IVIIM-DWI parameters are helpful for the identification of different AS disease activity levels and are superior to traditional DWI. IVIM-DWI quantitative parameters had a good correlation with the SPARCC score.
ADVANCES IN KNOWLEDGE
A new MR technology-quantitative parameters of IVIM-DWI contribute to the identification of AS disease activity. IVIM-DWI quantitative parameters were well correlated with the SPARCC score.
目的
探讨 3.0T 磁共振体素内不相干运动扩散（IVIM-DWI）定量参数在鉴别强直性脊柱炎（AS）不同疾病活动状态中的价值，并与传统弥散加权成像（DWI）及加拿大脊柱关节炎研究协会（SPARCC）评分进行比较。
方法
纳入 56 例 AS 患者（活动组、非活动组）和 24 例健康对照者，采集临床资料、IVIM-DWI 磁共振图像定量参数及 SPARCC 评分。采用 Kruskal-Wallis 检验比较各组间差异。采用直方图数据及 SPARCC 评分的受试者工作特征（ROC）曲线分析对三组的效能进行识别。采用 Spearman 相关系数分析定量 IVIM-DWI 参数与 SPARCC 评分的相关性。
结果
活动组 f（10%）及 SPARCC 评分明显高于非活动组，活动组 f（10%、25%、50%）、D（平均、熵、10%90%）、D（峰度、偏度）、ADC（平均、10%90%）及 SPARCC 评分明显高于对照组（P<0.05）。在活动组与非活动组的鉴别中，SPARCC 评分的 AUC 最高（0.799），其截断值为 12 时，灵敏度和特异度分别为 69.23%、82.35%。SPARCC 评分与各百分位数及平均值均呈正相关。
结论
定量 IVIM-DWI 参数有助于鉴别不同 AS 疾病活动水平，且优于传统 DWI。IVIM-DWI 定量参数与 SPARCC 评分具有良好的相关性。
知识进展
一种新的磁共振技术——IVIM-DWI 定量参数有助于 AS 疾病活动的识别。IVIM-DWI 定量参数与 SPARCC 评分相关性良好。
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