Zhang P, Yu K, Guo R, Shah S, Morelli J N, Runge V A, Li X
Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095, Jiefang Road, Wuhan City, Hubei Province 430030, China.
Department of Radiology, Xianning Central Hospital, Hubei University of Science and Technology, Hubei Province, China.
Clin Radiol. 2015 Jan;70(1):62-6. doi: 10.1016/j.crad.2014.09.015. Epub 2014 Oct 22.
To analyse the correlations between clinical and MRI sacroiliitis activity indices in ankylosing spondylitis (AS).
Sixteen normal volunteers and 52 patients were enrolled. The clinical AS activity indices included the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) score, serum high-sensitivity C-reactive protein, and erythrocyte sedimentation rate. The MRI sacroiliitis activity indices included apparent diffusion coefficient (ADC) values of bone and the Spondyloarthritis Research Consortium of Canada (SPARCC) score.
The mean SPARCC score of the control group was 0 and of the AS group was 9.9 ± 9.1 (range 0-36). The mean ADC value of the AS group was statistically significantly higher than that of the control group (49.7 ± 20.2 × 10(-5)mm(2)/s versus 38.9 ± 5.3 × 10(-5)mm(2)/s, p < 0.05). The BASDAI score showed a statistically significant correlation with the SPARCC score (r = 0.685, p < 0.05) and with ADC values (r = 0.329, p < 0.05). ADC values correlated with the SPARCC score (r = 0.390, p < 0.05).
ADC values and the SPARCC index may be useful activity indices in AS.
分析强直性脊柱炎（AS）临床与MRI骶髂关节炎活动指数之间的相关性。
纳入16名正常志愿者和52例患者。AS临床活动指数包括巴斯强直性脊柱炎疾病活动指数（BASDAI）评分、血清高敏C反应蛋白和红细胞沉降率。MRI骶髂关节炎活动指数包括骨表观扩散系数（ADC）值和加拿大脊柱关节炎研究联盟（SPARCC）评分。
对照组SPARCC评分均值为0，AS组为9.9±9.1（范围0 - 36）。AS组的平均ADC值显著高于对照组（49.7±20.2×10⁻⁵mm²/s对38.9±5.3×10⁻⁵mm²/s，p<0.05）。BASDAI评分与SPARCC评分（r = 0.685，p<0.05）以及ADC值（r = 0.329，p<0.05）均呈显著相关性。ADC值与SPARCC评分相关（r = 0.390，p<0.05）。
ADC值和SPARCC指数可能是AS有用的活动指数。
