Centro de Biología Molecular Severo Ochoa (CBMSO), Consejo Superior de Investigaciones Científicas (CSIC)-Universidad Autónoma de Madrid (UAM), Madrid, Spain (J.O., E.G.-R., M.M.).
Instituto de Investigación Sanitaria del Hospital 12 de Octubre (i+12), Madrid, Spain (J.O., E.G.-R., M.M.).
Arterioscler Thromb Vasc Biol. 2022 Apr;42(4):462-469. doi: 10.1161/ATVBAHA.121.317346. Epub 2022 Feb 24.
The goal of this study was to determine whether boosting mitochondrial respiration prevents the development of fatal aortic ruptures triggered by atherosclerosis and hypertension.
Ang-II (angiotensin-II) was infused in ApoE (Apolipoprotein E)-deficient mice fed with a western diet to induce acute aortic aneurysms and lethal ruptures.
We found decreased mitochondrial respiration and mitochondrial proteins in vascular smooth muscle cells from murine and human aortic aneurysms. Boosting NAD levels with nicotinamide riboside reduced the development of aortic aneurysms and sudden death by aortic ruptures.
Targetable vascular metabolism is a new clinical strategy to prevent fatal aortic ruptures and sudden death in patients with aortic aneurysms.
本研究旨在确定通过增强线粒体呼吸是否可以预防由动脉粥样硬化和高血压引发的致命性主动脉破裂。
在给予西方饮食的载脂蛋白 E（ApoE）缺陷小鼠中输注血管紧张素 II（Ang-II），以诱导急性主动脉瘤和致命性破裂。
我们发现，从人和鼠的主动脉瘤中血管平滑肌细胞的线粒体呼吸和线粒体蛋白均减少。用烟酰胺核糖苷增加 NAD 水平可减少主动脉瘤的发展，并降低因主动脉破裂导致的突然死亡。
可靶向的血管代谢是预防主动脉瘤患者发生致命性主动脉破裂和突然死亡的新临床策略。
