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与乳腺乳头状病变相关的硅胶暴露:一例报告。

Silicone exposure associated with breast papillary lesion: A case report.

作者信息

Fleury Eduardo de Faria Castro

机构信息

Radiologist at Instituto Brasileiro de Controle do Câncer - IBCC, São Paulo, Brasil.

出版信息

Radiol Case Rep. 2022 Feb 9;17(4):1261-1265. doi: 10.1016/j.radcr.2022.01.026. eCollection 2022 Apr.

Abstract

We described a breast papillary lesion related to silicone breast implant exposure. The case report is in accordance with our initial publication, where we proposed that silicone particles may trigger a process of reverse morphogenesis in pericapsular tissue resulting in metaplasia of the epithelial cells. The relationship between breast metaplasia and silicone implants is still little discussed in the literature. Our current study is based on evidence obtained from the files of a patient with a six-year-old history of silicone breast implant, which resulted in a diagnosis of a papillary lesion after a percutaneous breast biopsy. Currently, the main complications related to implants reported in the literature are intra- and extra-capsular ruptures, capsular contracture, and the most severe, breast implant-associated anaplastic large cell lymphoma. However, another complication not yet widely accepted in the literature is breast implant illness, resulting from silicone induced granuloma of breast implant capsule. Many medical specialists are skeptical about silicone disease potential and argue the lack of scientific evidence to support its existence. We believe that presenting these findings and the appropriate discussion of the results should contribute to a better understanding of the pathologies related to breast implants. It is worth mentioning that the safety of breast implants must be questioned.

摘要

我们描述了一例与硅胶乳房植入物暴露相关的乳腺乳头状病变。该病例报告与我们最初的出版物一致,在该出版物中我们提出硅胶颗粒可能引发包膜周围组织的反向形态发生过程,导致上皮细胞化生。乳腺化生与硅胶植入物之间的关系在文献中仍很少被讨论。我们目前的研究基于从一名有六年硅胶乳房植入病史的患者档案中获得的证据,该患者经皮乳房活检后被诊断为乳头状病变。目前,文献中报道的与植入物相关的主要并发症是囊内和囊外破裂、包膜挛缩,以及最严重的乳房植入物相关间变性大细胞淋巴瘤。然而,文献中尚未被广泛接受的另一种并发症是乳房植入物疾病,它由硅胶诱导的乳房植入物包膜肉芽肿引起。许多医学专家对硅胶疾病的可能性持怀疑态度,并认为缺乏支持其存在的科学证据。我们相信展示这些发现并对结果进行适当讨论应有助于更好地理解与乳房植入物相关的病理情况。值得一提的是,乳房植入物的安全性必须受到质疑。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb34/8841957/0c626353ba92/gr1.jpg

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