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海分枝杆菌感染与干扰素-γ释放试验交叉反应:一例报告

Mycobacterium marinum Infection and Interferon-Gamma Release Assays Cross-Reactivity: A Case Report.

作者信息

Patel Premalkumar M, Camps Nicholas, Rivera Cynthia I, Tuda Claudio, VanOstran Garrett

机构信息

Infectious Disease, Mount Sinai Medical Center, Miami Beach, USA.

Internal Medicine, Mount Sinai Medical Center, Miami Beach, USA.

出版信息

Cureus. 2022 Jan 19;14(1):e21420. doi: 10.7759/cureus.21420. eCollection 2022 Jan.

DOI:10.7759/cureus.21420
PMID:35198325
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8856640/
Abstract

is a pathogen that causes skin and soft tissue infections in people who work with contaminated water, such as fish handlers. infection is mostly limited to patients with compromised immune systems. As per current guidelines, susceptibility testing is not routinely recommended although sporadic cases have been reported with resistance to routinely prescribed anti-tuberculous drugs. We report a case of a 61-year-old male taking adalimumab with ulcerative skin and soft tissue infection with positive interferon-gamma release assays (IGRA) identified as and the treatment challenges involved in this case.

摘要

是一种病原体,可导致接触受污染水的人群(如鱼类处理人员)发生皮肤和软组织感染。感染大多局限于免疫系统受损的患者。根据现行指南,虽然有零星病例报告对常规开具的抗结核药物耐药,但不常规推荐进行药敏试验。我们报告了一例61岁男性病例,该患者正在服用阿达木单抗,患有溃疡性皮肤和软组织感染,干扰素-γ释放试验(IGRA)呈阳性,病原体鉴定为[具体病原体未给出],以及该病例所涉及的治疗挑战。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a18a/8856640/2f6856f9e300/cureus-0014-00000021420-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a18a/8856640/1caefc708e07/cureus-0014-00000021420-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a18a/8856640/2f6856f9e300/cureus-0014-00000021420-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a18a/8856640/1caefc708e07/cureus-0014-00000021420-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a18a/8856640/2f6856f9e300/cureus-0014-00000021420-i02.jpg

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本文引用的文献

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Mycobacterium marinum infection in fish and man: epidemiology, pathophysiology and management; a review.鱼类和人类分枝杆菌感染:流行病学、病理生理学和管理;综述。
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Increased risk of mycobacterial infections associated with anti-rheumatic medications.抗风湿药物相关的分枝杆菌感染风险增加。
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