Fujimoto Ayumi, Hamaguchi Shunichi, Suzuki Ritsuro
Department of Hematology, Shimane University Hospital, Izumo, Japan.
Department of Internal Medicine, Division of Medical Oncology and Respiratory Medicine, Shimane University Faculty of Medicine, Izumo, Japan.
Leuk Res Rep. 2022 Feb 7;17:100290. doi: 10.1016/j.lrr.2022.100290. eCollection 2022.
We report a case of 43-year-old woman diagnosed with essential thrombocythemia in 1992. She was diagnosed with secondary myelofibrosis in 2011. Later, she suffered mild dyspnea, which gradually worsened. She was admitted to our hospital to evaluate the cause in 2014. Chest computed tomography showed ground-glass opacity (GGO) in the lungs. A lung biopsy revealed various hematopoietic cells, including abnormal megakaryocytes, infiltrating the alveolar septum, suggesting pulmonary extramedullary hematopoiesis. She was successfully treated by ruxolitinib and her disease is well controlled for more than 7 years. To keep this phenomenon in mind when see the patients with dyspnea is important.
我们报告一例43岁女性病例，该患者于1992年被诊断为原发性血小板增多症。2011年她被诊断为继发性骨髓纤维化。后来，她出现轻度呼吸困难，并逐渐加重。2014年她因评估病因入住我院。胸部计算机断层扫描显示肺部有磨玻璃影（GGO）。肺活检显示各种造血细胞，包括异常巨核细胞，浸润肺泡间隔，提示肺髓外造血。她接受鲁索替尼治疗成功，疾病得到良好控制超过7年。当见到呼吸困难的患者时记住这种现象很重要。
