University Hospital for Children and Adolescents, Neuropaediatrics, Ernst-Heydemann-Straße 8, Rostock, 18057, Germany.
Clinical Pharmacy, Institute of Pharmacy, Medical Faculty, Leipzig University, Brüderstraße 32, Leipzig, 04103, Germany.
Eur J Pediatr. 2022 May;181(5):2161-2171. doi: 10.1007/s00431-022-04419-6. Epub 2022 Feb 23.
Experienced drug-handling problems and inadequately considered expectations for drug therapy have an unfavorable influence on therapy. We performed a questionnaire survey in (i) parents of 0-5-year-old children and (ii) 6-17-year olds and their parents. We assessed (A) experienced drug-handling problems and (B) expectations for drug therapy. (i) Forty-six parents and (ii) 103 children and their parents participated in the study. Experienced drug-handling problems were described by (i) 100% of parents and (ii) 62% of children and 70% of parents. Problems concerned with the preparation of the drug, dosing, compliance with the time interval, and acceptance. (i) Sixty-five percent of parents preferred a peroral route of drug administration, while (ii) 74% of children and 86% of parents did so. Preferred characteristics of peroral drug formulations, e.g., liquid versus solid drug formulations or flavor, were highly heterogeneous. Preferences of 6-17-year-old children and their parents matched in 43 to 66%. Conclusion: Most children and their parents had already experienced drug-handling problems. Preferences concerning the ideal pediatric drug were highly heterogeneous and in about half of cases, preferences of children and their parents differed. Thus, the children should be approached directly. If information is solely gained from parents, the children's needs might remain unmet. What is Known: • Pediatric drug administration is complex and therefore error-prone. • Experiences and expectations of children and their parents should be considered. What is New: •Most pediatric patients and their parents have already experienced drug-handling problems. • Expectations concerning the ideal pediatric drug are highly heterogeneous. Parents are often insufficiently aware of those expectations in their children.
处理药物方面经验不足和对药物治疗考虑不充分会对治疗产生不利影响。我们对（i）0-5 岁儿童的父母和（ii）6-17 岁儿童及其父母进行了问卷调查。我们评估了（A）处理药物方面的经验和（B）对药物治疗的期望。（i）有 46 位父母和（ii）103 位儿童及其父母参与了研究。药物处理方面的问题在（i）100%的父母和（ii）62%的儿童和 70%的父母中均有描述。这些问题涉及药物的准备、剂量、遵守时间间隔和接受度。（i）65%的父母更喜欢口服给药途径，而（ii）74%的儿童和 86%的父母更喜欢这种方式。口服药物制剂的首选特征，例如液体与固体药物制剂或口味，存在高度的异质性。6-17 岁儿童及其父母的偏好有 43%到 66%是匹配的。结论：大多数儿童及其父母已经经历了药物处理方面的问题。对于理想儿科药物的偏好存在高度的异质性，而且在大约一半的情况下，儿童及其父母的偏好不同。因此，应该直接与儿童接触。如果仅从父母那里获取信息，儿童的需求可能得不到满足。已知情况：• 儿科药物给药复杂，因此容易出错。• 应考虑儿童及其父母的经验和期望。新情况：• 大多数儿科患者及其父母已经经历了药物处理方面的问题。• 对理想儿科药物的期望存在高度的异质性。父母往往对孩子的这些期望认识不足。
