UGC de Aparato Digestivo , Hospital Universitario Reina Sofía, España.
Rev Esp Enferm Dig. 2022 Jul;114(7):429-430. doi: 10.17235/reed.2022.8635/2021.
Mesalazine is the most widely used aminosalicylate for induction and maintenance of remission in patients with mild-to-moderate ulcerative colitis (UC). Drug-induced hypersensitivity pneumonitis is considered very rare (<1/10.000 patients). Due to its rarity and the scarce cases reported, mesalazine-induced lung injury needs to be highly suspected in a patient with onset of respiratory symptoms and UC under treatment with salicylates. It should make the clinician formulate a differential diagnosis that includes not only infections (tuberculosis, bacterial...) or the inflammatory bowel disease itself, but also the current coronavirus disease 2019 (COVID-19) since their clinical and radiological manifestations may be very similar.
美沙拉嗪是最广泛用于诱导和维持轻中度溃疡性结肠炎（UC）缓解的氨基水杨酸盐。药物诱导性过敏反应性肺炎被认为非常罕见（<1/10000 患者）。由于其罕见性和报告的病例稀少，在接受水杨酸盐治疗的 UC 患者出现呼吸道症状时，需要高度怀疑美沙拉嗪引起的肺损伤。这应该使临床医生制定一个鉴别诊断，不仅包括感染（结核、细菌等）或炎症性肠病本身，还包括当前的 2019 年冠状病毒病（COVID-19），因为它们的临床和放射学表现可能非常相似。
