Maezawa Yosuke, Okada Kenta, Ariga Hiroyuki, Kashimura Junya, Okauchi Shinichiro, Satoh Hiroaki
Division of General Medicine, Mito Medical Center, University of Tsukuba-Mito Kyodo General Hospital, Ibaraki, Japan.
Division of Gastroenterology, Mito Medical Center, University of Tsukuba-Mito Kyodo General Hospital, Ibaraki, Japan.
Maedica (Bucur). 2023 Dec;18(4):718-721. doi: 10.26574/maedica.2023.18.4.718.
Mesalazine is a drug used to treat ulcerative colitis and Crohn's disease, and is known to rarely cause lung injury. We show herein a unique case who developed this drug-induced injury. A 17-year-old boy presented with fever and anorexia after administration of mesalazine. Computed tomography showed extensive ground-glass opacities with peripheral distribution in both lungs. He had general weakness, but had no respiratory symptoms such as cough and dyspnea. With prednisolone, which is primarily aimed at controlling ulcerative colitis, the extensive opacity in both lungs were improved. All patients with this drug-induced lung injury reported to date have had respiratory symptoms, but this patient had no subjective respiratory symptoms and had no abnormalities in respiratory rate and oxyhaemoglobin saturation. Although very rare, we do believe that this clinical course will provide some suggestive information on treatment for patients with similar course in the future.
美沙拉嗪是一种用于治疗溃疡性结肠炎和克罗恩病的药物，已知极少会引起肺损伤。我们在此展示了一例发生这种药物性损伤的独特病例。一名17岁男孩在服用美沙拉嗪后出现发热和食欲不振。计算机断层扫描显示双肺广泛的外周分布的磨玻璃影。他全身无力，但没有咳嗽和呼吸困难等呼吸道症状。使用主要用于控制溃疡性结肠炎的泼尼松龙后，双肺广泛的模糊影得到改善。迄今为止报告的所有这种药物性肺损伤患者都有呼吸道症状，但该患者没有主观呼吸道症状，呼吸频率和氧合血红蛋白饱和度也没有异常。尽管非常罕见，但我们确实认为这一临床过程将为未来类似病程的患者治疗提供一些提示性信息。
