Department of Anatomy, Physiology and Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, AL, United States.
Department of Anatomy, Physiology and Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, AL, United States.
Prog Mol Biol Transl Sci. 2019;161:91-112. doi: 10.1016/bs.pmbts.2018.09.003. Epub 2018 Oct 30.
The β-adrenergic receptor (β-AR) is an important regulator of various physiological functions, such as thermogenesis in brown adipose tissue, lipolysis in white adipose tissue, negative inotropic effect in cardiomyocyte, and relaxation in blood vessel. The activation of β-AR by its agonists is shown to have metabolic (antiobesity and antidiabetic) and cardiovascular effects in animal models, highlighting β-AR as a potential therapeutic target in the treatment of several human diseases. Moreover, a substantial number of studies performed on different populations have identified some β-AR polymorphic variants associated with obesity, diabetes, cardiovascular diseases, and other disorders. The clinical phenotypes and functional characteristics of these variants provide insights into potential pathophysiological roles of β-AR in the development of these diseases.
β-肾上腺素能受体（β-AR）是调节多种生理功能的重要分子，如棕色脂肪组织的产热、白色脂肪组织的脂肪分解、心肌细胞的负性肌力作用以及血管的舒张。其激动剂激活β-AR 在动物模型中表现出代谢（抗肥胖和抗糖尿病）和心血管作用，凸显了β-AR 作为治疗多种人类疾病的潜在治疗靶点。此外，在不同人群中进行的大量研究已经确定了一些与肥胖、糖尿病、心血管疾病和其他疾病相关的β-AR 多态性变体。这些变体的临床表型和功能特征为β-AR 在这些疾病发展中的潜在病理生理作用提供了线索。
