胆囊切除标本中非肿瘤性病变：一项三级保健中心的描述性横断面研究。

Non-neoplastic Lesions of Gallbladder Among Cholecystectomy Specimens of a Tertiary Care Center: A Descriptive Cross-sectional Study.

机构信息

Department of Pathology, Manipal College of Medical Science, Pokhara, Nepal.

Department of Radiology, Charak Medical Hospital, Pokhara, Nepal.

出版信息

JNMA J Nepal Med Assoc. 2021 Oct 15;59(242):970-974. doi: 10.31729/jnma.5861.

DOI:10.31729/jnma.5861

PMID:35199708

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9107806/

Abstract

INTRODUCTION

Gallbladder diseases are prevalent worldwide and present with a diverse histopathological spectrum. Mucosal irritation and chronic inflammation is considered as an important etiological factor for the mechanical or functional dysfunction of emptying of the gallbladder. This study aims to find the prevalence of non-neoplastic lesions of gallbladder among cholecystectomy specimens of a tertiary care center.

METHODS

A descriptive cross-sectional study was conducted in the Department of Pathology, of a tertiary care center from January 2005 to December 2020. Ethical approval was taken from the Institutional Review Committee. All the patients who had undergone cholecystectomy procedures which showed non-neoplastic lesions were enrolled in the study. Convenient sampling was done. Statistical Package for Social Sciences version 21 and Microsoft Excel were used for data analysis. Point estimate at 95% Confidence Interval was calculated along with frequency and proportion for binary data.

RESULTS

Out of 4914 cholecystectomy specimens, 4852 (98.73%) (95% Confidence Interval= 98.42- 99.04) were non-neoplastic lesions. There were 1252 (25.8%) males and 3600 (74.2%) females with a male to female ratio of 1:2.87. Age ranged from 2 to 89 years with a mean age of 45±14.48 years. Gallbladder lesions were observed maximum in age group 41-50 years with 1200 (24.7%) cases. Among the non-neoplastic lesions, cholecystitis without any specific finding was the most common finding with 3028 (62.4%) cases followed by cholelithiasis with 1478 (30.5%) cases.

CONCLUSIONS

The prevalence of non-neoplastic lesions of gallbladder is similar to other studies done in similar setings. Female predominance was noted in non-neoplastic lesions.

摘要

简介

胆囊疾病在全球范围内普遍存在，表现出多种组织病理学谱。黏膜刺激和慢性炎症被认为是胆囊排空机械或功能障碍的重要病因。本研究旨在探讨三级保健中心胆囊切除术标本中非肿瘤性病变的发生率。

方法

本研究为 2005 年 1 月至 2020 年 12 月在三级保健中心病理学系进行的描述性横断面研究。本研究获得了机构审查委员会的批准。所有接受过胆囊切除术且显示非肿瘤性病变的患者均纳入本研究。采用便利抽样法。使用社会科学统计软件包（SPSS）版本 21 和 Microsoft Excel 进行数据分析。计算了 95%置信区间的点估计值，以及二元数据的频率和比例。

结果

在 4914 例胆囊切除术标本中，有 4852 例（98.73%）（95%置信区间=98.42-99.04）为非肿瘤性病变。男性 1252 例（25.8%），女性 3600 例（74.2%），男女比例为 1:2.87。年龄 2-89 岁，平均年龄 45±14.48 岁。胆囊病变在 41-50 岁年龄组中观察到最多，有 1200 例（24.7%）。在非肿瘤性病变中，无特定发现的胆囊炎是最常见的病变，有 3028 例（62.4%），其次是胆石症，有 1478 例（30.5%）。