School of Pharmacy, Jiangxi Science & Technology Normal University, Nanchang, 330013, Jiangxi, P. R. China.
Org Biomol Chem. 2022 Mar 9;20(10):2109-2114. doi: 10.1039/d2ob00018k.
An efficient silver-mediated oxidative trifluoromethylthiolation of unsaturated carboxylic acids to construct trifluoromethylthiol-containing lactones has been disclosed. In this protocol no metal-catalysts was added, and preliminary mechanism investigations suggested that a free-radical pathway should be involved in the process. High functional group tolerance and excellent yields were demonstrated by the efficient preparation of a wide range of γ-trifluoromethylthiolated phthalides.
本文报道了一种高效的银介导不饱和羧酸的氧化三氟甲基化反应，用于构建含三氟甲基硫的内酯。该反应无需金属催化剂，初步的机理研究表明该反应可能涉及自由基途径。通过高效制备一系列γ-三氟甲基化邻苯二甲酸内酯，证明了该方法具有高官能团容忍性和优异的产率。
