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药物相关性颌骨坏死:一个位于北昆士兰的单中心病例系列。

Medication-related osteonecrosis of the jaws: a single centre, Far North Queensland case series.

机构信息

Cairns Dental Anaesthetic Centre, Cairns, Queensland, Australia.

Oral and Maxillofacial Surgeon, Cairns, Queensland, Australia.

出版信息

Aust Dent J. 2022 Jun;67(2):168-171. doi: 10.1111/adj.12905. Epub 2022 Mar 18.

DOI:10.1111/adj.12905
PMID:35199861
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9544475/
Abstract

Medication-related osteonecrosis of the jaws (MRONJ) is a painful debilitating condition which is considered rare in the medical literature available to prescribers. Dentists, however, are likely to trigger this condition through extractions and implants. Anecdotally MRONJ appears more common than first thought. This paper presents 13 cases of MRONJ diagnosed and treated by a single oral and maxillofacial surgeon based in Cairns, Far North Queensland, in a 2-year period. The management of these cases is presented. The two cases where MRONJ resulted in the loss of dental implants are highlighted. © 2022 Australian Dental Association.

摘要

药物相关性颌骨坏死(MRONJ)是一种痛苦且使人虚弱的疾病,在可用于处方的医学文献中被认为很少见。然而,牙医通过拔牙和植入物可能会引发这种情况。据传闻,MRONJ 似乎比最初想象的更为常见。本文介绍了在 2 年内,由一名位于昆士兰北部凯恩斯的口腔颌面外科医生诊断和治疗的 13 例 MRONJ 病例。介绍了这些病例的处理方法。突出了导致种植牙丧失的 2 例 MRONJ 病例。©2022 澳大利亚牙科协会。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b677/9544475/2a53b9cd6473/ADJ-67-168-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b677/9544475/4dd2207b35a7/ADJ-67-168-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b677/9544475/2a53b9cd6473/ADJ-67-168-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b677/9544475/4dd2207b35a7/ADJ-67-168-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b677/9544475/2a53b9cd6473/ADJ-67-168-g002.jpg

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本文引用的文献

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Bisphosphonate-Related Osteonecrosis of the Jaw.双膦酸盐相关颌骨坏死
J Am Dent Assoc. 2016 Oct;147(10):776-7. doi: 10.1016/j.adaj.2016.08.015.
2
American Association of Oral and Maxillofacial Surgeons position paper on medication-related osteonecrosis of the jaw--2014 update.美国口腔颌面外科医师协会关于药物相关性颌骨坏死的立场文件——2014年更新版
J Oral Maxillofac Surg. 2014 Oct;72(10):1938-56. doi: 10.1016/j.joms.2014.04.031. Epub 2014 May 5.
3
A C-terminal crosslinking telopeptide test-based protocol for patients on oral bisphosphonates requiring extraction: a prospective single-center controlled study.
一项针对需要拔牙的口服双膦酸盐类药物患者的基于C末端交联端肽检测的方案:一项前瞻性单中心对照研究。
J Oral Maxillofac Surg. 2014 Aug;72(8):1456-62. doi: 10.1016/j.joms.2014.02.036. Epub 2014 Mar 3.
4
The nature and frequency of bisphosphonate-associated osteonecrosis of the jaws in dental implant patients: a South Australian case series.牙种植患者中双膦酸盐相关颌骨坏死的性质和发生率:南澳大利亚病例系列
J Oral Maxillofac Surg. 2010 Feb;68(2):337-43. doi: 10.1016/j.joms.2009.09.037.
5
Clinical investigation of C-terminal cross-linking telopeptide test in prevention and management of bisphosphonate-associated osteonecrosis of the jaws.C末端交联端肽检测在双膦酸盐相关颌骨骨坏死防治中的临床研究
J Oral Maxillofac Surg. 2009 Jun;67(6):1167-73. doi: 10.1016/j.joms.2009.02.004.
6
Bisphosphonate-associated osteonecrosis of the jaw: report of a task force of the American Society for Bone and Mineral Research.双膦酸盐相关颌骨骨坏死:美国骨与矿物质研究学会特别工作组报告
J Bone Miner Res. 2007 Oct;22(10):1479-91. doi: 10.1359/jbmr.0707onj.
7
Nature and frequency of bisphosphonate-associated osteonecrosis of the jaws in Australia.澳大利亚双膦酸盐相关颌骨坏死的性质和发生率
J Oral Maxillofac Surg. 2007 Mar;65(3):415-23. doi: 10.1016/j.joms.2006.10.061.