Rheumatology Clinic, Ospedale Carlo Urbani, Università Politecnica delle Marche, Jesi, Ancona, Italy.
Rheumatology Unit, Internal Medicine Department, ASST Fatebenefratelli-Sacco, Milan; University School of Medicine, Milan, Italy.
Clin Exp Rheumatol. 2022 Jun;40(6):1091-1101. doi: 10.55563/clinexprheumatol/9mbbpb. Epub 2022 Feb 4.
The aim of this study was to evaluate the prevalence and severity of overactive bladder syndrome (OAB) and sexual dysfunction in fibromyalgia (FM) patients, as well as their relationship with disease severity.
Consecutive adult female patients with FM were enrolled. Patients filled in a comprehensive questionnaire package including demographic variables, disease severity assessment (revised Fibromyalgia Impact Questionnaire [FIQR]), neuropathic pain features (PainDetect Questionnaire [PDQ]), severity of OAB symptoms (Overactive Bladder Symptom Score [OABSS]), and determining sexual functioning (Female Sexual Function Index [FSFI]).
The study included 481 patients, 116 (24.11%) had mild OAB, 82 patients (17.04%) had moderate OAB, and 34 patients had serious OAB (7.06%). In 14.17% of patients the bladder condition was causing them major issues in terms of discomfort. In 7.87% of patients the bladder condition was causing them significant problems. Sexual dysfunctions were found in 91 patients (18.91%). Using the FSFI as dependent variable, multivariate analysis revealed a positive relationship between sexual dysfunction and variables of disease burden (FIQR, p<0.0001; PDQ, p<0.0001, widespread pain index [WPI], p=0.0037). Using OABSS as the dependent variable, multivariate regression revealed a substantial contribution from FIQR (p<0.0001), PDQ (p=0.0037), and WPI (p=0.0030).
FM has the potential to affect both psychological and physiological processes in women with OAB and sexual dysfunction. These results emphasize the importance of a multidisciplinary approach to treat patients with overactive bladder syndrome and sexual dysfunction in FM.
本研究旨在评估纤维肌痛（FM）患者中膀胱过度活动症（OAB）和性功能障碍的患病率和严重程度，以及它们与疾病严重程度的关系。
连续纳入成年女性 FM 患者。患者填写了一份综合问卷，包括人口统计学变量、疾病严重程度评估（修订后的纤维肌痛影响问卷 [FIQR]）、神经病理性疼痛特征（疼痛检测问卷 [PDQ]）、OAB 症状严重程度（OAB 症状评分 [OABSS]），以及确定性功能（女性性功能指数 [FSFI]）。
研究共纳入 481 例患者，116 例（24.11%）为轻度 OAB，82 例（17.04%）为中度 OAB，34 例为严重 OAB（7.06%）。14.17%的患者因膀胱状况而感到不适。7.87%的患者因膀胱状况而出现严重问题。91 例患者（18.91%）存在性功能障碍。使用 FSFI 作为因变量，多变量分析显示性功能障碍与疾病负担变量呈正相关（FIQR，p<0.0001；PDQ，p<0.0001，广泛疼痛指数 [WPI]，p=0.0037）。使用 OABSS 作为因变量，多元回归显示 FIQR（p<0.0001）、PDQ（p=0.0037）和 WPI（p=0.0030）有较大贡献。
FM 有可能影响 OAB 和性功能障碍女性的心理和生理过程。这些结果强调了对患有 OAB 和性功能障碍的 FM 患者采取多学科治疗方法的重要性。
