Zhou Kun, Rao Zehui, Chen Ingyu, Guo Zhen, Luo Jun, Zhang Yida
Department of Urology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330000, China.
Key Laboratory of Urinary System Diseases of Jiangxi Province, Nanchang, China.
Sci Rep. 2025 Jul 28;15(1):27395. doi: 10.1038/s41598-025-13129-6.
Overactive bladder (OAB) significantly affects places a considerable economic strain and individuals' quality of life on global healthcare resources.The ratio of red cell distribution width to albumin (RAR) is a novel inflammatory marker, yet its association with the prevalence of OAB among adults in the U.S. remains unclear. This nationally representative cross-sectional study utilized data derived from the 2005-2020 National Health and Nutrition Examination Survey (NHANES), focusing primarily on individuals aged 20 and older with complete information on red cell distribution width (RDW) and albumin. Subgroup analyses, multivariate logistic regression, and restricted cubic spline (RCS) models were employed to investigate the association of the risk of OAB and the levels of RAR. Additionally, receiver operating characteristic (ROC) curves were used to evaluate the predictive performance of RAR levels for OAB.An overall of 26,987 participants aged over 20 years were included in the analysis, of whom 4,943 were diagnosed with OAB. Both before and after adjusting for potential confounders, the results consistently indicated a significant positive correlation of RAR with the risk of OAB. Using the first quartile (Q1) of RAR as the reference, people in the highest quartile (Q4) had a 41% increased risk of OAB relative to those in Q1 after adjusting for all covariates. The RCS curve revealed a nonlinear relationship between RAR and OAB. Furthermore, interaction tests and subgroup analyses indicated that age modified the positive correlation between OAB and RAR. ROC curve analysis revealed that the cutoff value for predicting OAB with RAR was 3.07 (specificity: 57.70%, sensitivity: 64.64%, AUC: 0.649).In U.S. adults, elevated levels of RAR are related to an increased risk of OAB. RAR levels may serve as a potential marker for the development of OAB.
膀胱过度活动症（OAB）对全球医疗资源造成了相当大的经济负担，并严重影响个人生活质量。红细胞分布宽度与白蛋白之比（RAR）是一种新型炎症标志物，但其与美国成年人中OAB患病率的关联尚不清楚。这项具有全国代表性的横断面研究利用了2005 - 2020年国家健康和营养检查调查（NHANES）的数据，主要关注年龄在20岁及以上且拥有红细胞分布宽度（RDW）和白蛋白完整信息的个体。采用亚组分析、多变量逻辑回归和受限立方样条（RCS）模型来研究OAB风险与RAR水平之间的关联。此外，使用受试者工作特征（ROC）曲线来评估RAR水平对OAB的预测性能。
分析共纳入了26,987名年龄超过20岁的参与者，其中4,943人被诊断为OAB。在调整潜在混杂因素前后，结果一致表明RAR与OAB风险呈显著正相关。以RAR的第一四分位数（Q1）为参照，在调整所有协变量后，处于最高四分位数（Q4）的人群患OAB的风险相对于Q1人群增加了41%。RCS曲线显示RAR与OAB之间存在非线性关系。此外，交互作用检验和亚组分析表明年龄改变了OAB与RAR之间的正相关关系。ROC曲线分析显示，用RAR预测OAB的截断值为3.07（特异性：57.70%，敏感性：64.64%，AUC：0.649）。
在美国成年人中，RAR水平升高与OAB风险增加有关。RAR水平可能作为OAB发生发展的潜在标志物。
