Ansari Sekhu, Kumar Vinay, Bhatt Dharmendra Nath, Irfan Mohammad, Datta Asis
Division of Pathology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Department of Physiology and Cell Biology, Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.
Bioengineering (Basel). 2022 Feb 5;9(2):64. doi: 10.3390/bioengineering9020064.
During evolution, both human and plant pathogens have evolved to utilize a diverse range of carbon sources. N-acetylglucosamine (GlcNAc), an amino sugar, is one of the major carbon sources utilized by several human and phytopathogens. GlcNAc regulates the expression of many virulence genes of pathogens. In fact, GlcNAc catabolism is also involved in the regulation of virulence and pathogenesis of various human pathogens, including , , , , and phytopathogens such as . Moreover, GlcNAc is also a well-known structural component of many bacterial and fungal pathogen cell walls, suggesting its possible role in cell signaling. Over the last few decades, many studies have been performed to study GlcNAc sensing, signaling, and metabolism to better understand the GlcNAc roles in pathogenesis in order to identify new drug targets. In this review, we provide recent insights into GlcNAc-mediated cell signaling and pathogenesis. Further, we describe how the GlcNAc metabolic pathway can be targeted to reduce the pathogens' virulence in order to control the disease prevalence and crop productivity.
在进化过程中，人类和植物病原体都已进化到能够利用多种碳源。N-乙酰葡糖胺（GlcNAc），一种氨基糖，是几种人类和植物病原体利用的主要碳源之一。GlcNAc调节病原体许多毒力基因的表达。事实上，GlcNAc分解代谢也参与各种人类病原体（包括 、 、 、 以及诸如 的植物病原体）的毒力和致病机制的调节。此外，GlcNAc也是许多细菌和真菌病原体细胞壁的著名结构成分，表明其在细胞信号传导中可能发挥的作用。在过去几十年里，已经进行了许多研究来研究GlcNAc的感知、信号传导和代谢，以便更好地理解GlcNAc在发病机制中的作用，从而确定新的药物靶点。在这篇综述中，我们提供了关于GlcNAc介导的细胞信号传导和发病机制的最新见解。此外，我们描述了如何针对GlcNAc代谢途径来降低病原体的毒力，以控制疾病流行率和作物生产力。
