Nottingham Breast Cancer Research Centre, University of Nottingham, Nottingham NG7 2RD, UK.
School of Medicine, Royal Derby Hospital Centre, Uttoxeter Road, University of Nottingham, Derby DE22 3DT, UK.
Curr Oncol. 2022 Jan 29;29(2):659-674. doi: 10.3390/curroncol29020058.
As our global population ages, we will see more cancer diagnoses in older adults. Surgery is an important treatment modality for solid tumours, forming the majority of all cancers. However, the management of older adults with cancer can be more complex compared to their younger counterparts. This narrative review will outline the current challenges facing older adults with cancer and potential solutions. The challenges facing older adults with cancer are complex and include lack of high-level clinical trials targeting older adults and selection of the right patient for surgery. This may be standard surgical treatment, minimally invasive surgery or alternative therapies (no surgery) which can be local or systemic. The next challenge is to identify the individual patient's vulnerabilities to allow them to be maximally optimised for treatment. Prehabilitation has been shown to be of benefit in some cancer settings but uniform guidance across all surgical specialties is required. Greater awareness of geriatric conditions amongst surgical oncologists and integration of geriatric assessment into a surgical clinic are potential solutions. Enhanced recovery programmes tailored to older adults could reduce postoperative functional decline. Ultimately, the greatest challenge an older adult with cancer may face is the mindset of their treating clinicians-a shared care approach between surgical oncologists and geriatricians is required.
随着全球人口老龄化,我们将看到更多的老年人被诊断出癌症。手术是治疗实体肿瘤的重要方法,也是大多数癌症的主要治疗方法。然而,与年轻患者相比,老年癌症患者的治疗管理可能更加复杂。本综述将概述老年癌症患者目前面临的挑战和潜在的解决方案。老年癌症患者面临的挑战是多方面的,包括缺乏针对老年人的高级别临床试验以及为手术选择合适的患者。这可能是标准的手术治疗、微创手术或替代疗法(不手术),可以是局部的或全身的。下一个挑战是确定个体患者的脆弱性,以使他们能够最大限度地接受治疗。康复前准备已被证明在某些癌症治疗中有益,但所有外科专业都需要统一的指导。提高外科肿瘤学家对老年病的认识,并将老年评估纳入外科诊所,是潜在的解决方案。为老年人量身定制的增强康复方案可以减少术后功能下降。最终,老年癌症患者可能面临的最大挑战是他们的治疗医生的思维模式——需要外科肿瘤学家和老年病学家之间的共同护理方法。