Friborg Jeppe, Koch Anders, Wohlfarht Jan, Storm Hans-Henrik, Melbye Mads
Department of Epidemiology Research, Danish Epidemiology Science Center, Statens Serum Institute, Artillerivej 5, 2300 Copenhagen S, Denmark.
Int J Cancer. 2003 Dec 20;107(6):1017-22. doi: 10.1002/ijc.11502.
The increasing westernization of the Arctic countries may influence the very particular cancer profile of these populations. Our objective was to investigate the development in cancer incidence from 1973 to 1997 in a large and well-defined Inuit population in Greenland. Greenland is part of the Danish Kingdom, and population statistics covering both countries are available from the same registry resource. Data from the Danish Civil Registration System and from the Danish Cancer Registry were used to calculate age-standardized cancer incidence rates for the periods 1973-1987 and 1988-1997 for persons born in Greenland. Using rates for Denmark, sex-specific standardized incidence ratios (SIRs) for 1988-1997 were calculated. Furthermore, age- and sex-specific incidence rates in the 2 periods were calculated for selected cancers. Total cancer incidence increased from 248.5 to 277.9 per 100,000 person-years in men and from 269.4 to 302.2 per 100,000 person-years in women. The incidence of lung, stomach, breast and colon cancer increased, whereas the incidence of cervical cancer decreased. Compared to the Caucasian population in Denmark, high SIRs were found for cancers of the nasopharynx, salivary gland, esophagus, stomach and cervix and low SIRs for testis, bladder, prostate, breast and hematologic cancers. Overall cancer incidence among Greenlandic Inuit is increasing as a result of increases in several cancers that are common in Western populations. A significant increase in the incidence of stomach cancer in both sexes, which contrasts global trends for this cancer, warrants further investigation.
北极国家日益西化的趋势可能会影响这些人群非常特殊的癌症发病情况。我们的目标是调查1973年至1997年格陵兰一大群界定明确的因纽特人群中癌症发病率的变化情况。格陵兰是丹麦王国的一部分，两国的人口统计数据可从同一登记资源获取。丹麦民事登记系统和丹麦癌症登记处的数据被用于计算1973 - 1987年和1988 - 1997年出生在格陵兰的人的年龄标准化癌症发病率。利用丹麦的发病率，计算了1988 - 1997年按性别划分的标准化发病比（SIRs）。此外，还计算了这两个时期特定选定癌症的年龄和性别发病率。男性的总癌症发病率从每10万人年248.5例增至277.9例，女性从每10万人年269.4例增至302.2例。肺癌、胃癌、乳腺癌和结肠癌的发病率上升，而宫颈癌的发病率下降。与丹麦的白种人群相比，发现鼻咽癌、唾液腺癌、食管癌、胃癌和宫颈癌的标准化发病比高，而睾丸癌、膀胱癌、前列腺癌、乳腺癌和血液系统癌症的标准化发病比低。由于西方人群中常见的几种癌症发病率上升，格陵兰因纽特人的总体癌症发病率正在增加。男女胃癌发病率均显著上升，这与该癌症的全球趋势相反，值得进一步调查。
